Elastic properties of the respiratory system in infants with cystic fibrosis.
Elastic properties of the respiratory system in infants with cystic fibrosis.
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囊性纤维化婴儿呼吸系统的弹性特性。
DOI：
10.1164/rccm.200401-132oc
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Kisling,Jeffrey
中科院分区：
文献类型：
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作者：
Tepper,RobertS;Weist,Andrea;Williams-Nkomo,Tamica;Kisling,Jeffrey
据报道，与健康对照受试者相比，囊性纤维化 (CF) 婴儿的呼吸系统顺应性 (Crs) 降低或没有差异；然而，报告的 Crs 测量是“准静态”的，或者是通过单次呼吸闭塞技术进行的，所有测量都仅限于潮气肺容量，并且使用吸气压力而不是呼气压力。我们通过测量从 30 cm H2O (V30) 的肺容积到 FRC 的静态通气压力-容积 (PV) 曲线，比较了患有 CF 的睡眠婴儿 (n = 10) 和健康对照受试者 (n = 34) 的呼吸系统的被动弹性特性。各组之间的 Crs 没有显着差异，Crs 是通过 5 cm H2O 和 15 cm H2O 气道松弛压之间的斜率（通气 PV 曲线的线性部分）来测量的。此外，当 PV 曲线标准化为 V30 时，患有 CF 的婴儿和健康对照受试者在任何气道压力下的分数体积之间没有差异。患有 CF 的婴儿的用力呼气流量明显较低；然而，较低的流量与 PV 曲线测量的体积分数无关。我们的研究结果表明，患有 CF 的婴儿呼吸系统具有正常的弹性。
Respiratory system compliance (Crs) in infants with cystic fibrosis (CF) has been reported as decreased or not different compared with healthy control subjects; however, the reported measurements of Crs were “quasi-static” or by the single-breath occlusion technique, with all measurements limited to tidal lung volume, as well as using inspiratory rather than expiratory pressures. We compared the passive elastic properties of the respiratory system of sleeping infants with CF (n = 10) and healthy control subjects (n = 34) by measuring static deflation pressure–volume (PV) curves from a lung volume at 30 cm H2O (V30) to FRC. There was no significant difference between the groups for Crs, which was measured as the slope between airway relaxation pressures of 5 and 15 cm H2O, the linear portion of the deflation PV curve. In addition, when PV curves were normalized to V30, there were no differences between the infants with CF and healthy control subjects in the fractional volumes at any airway pressure. The infants with CF had significantly lower forced expiratory flows; however, lower flows did not correlate with fractional volumes measured from the PV curve. Our findings indicate that infants with CF have normal elastic properties of the respiratory system.