Characteristics and Echogenicity of Clinical Ultrasound Contrast Agents: An In Vitro and In Vivo Comparison Study
Characteristics and Echogenicity of Clinical Ultrasound Contrast Agents: An In Vitro and In Vivo Comparison Study
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DOI：
10.7863/ultra.16.04059
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发表时间：
2017-05-01
影响因子：
2.3
通讯作者：
Frinking, Peter
中科院分区：
文献类型：
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作者：
Hyvelin, Jean-Marc;Gaud, Emmanuel;Frinking, Peter
目的比较三种市售超声造影剂SonoVue的理化特性和体内外超声造影成像性能（Bratum Imaging SpA，Colleretto Giacosa，意大利;在美国也以Lumason销售），（Lantheus Medical Imaging，North Billerica，MA）和Optison（GE Healthcare AS，奥斯陆，挪威）。方法用Multisizer Coulter计数器（Beckman Coulter，Fullerton，CA）测量理化特性。两种超声系统（Aplio 500; Toshiba Medical Systems Corp，Tochigi-ken，Japan;和Logiq E9; GE Healthcare，Little查尔丰，England）与不同的探头配合使用。使用定制的烧杯装置通过剂量范围测量在体外测量对比度增强;在猪（心脏和肝脏）和兔（肝脏）中比较体内成像性能。用VueBox定量分析软件（Brancial Suisse SA，Plan-les-Ouates，Switzerland）进行定量分析。体外数据表明，SonoVue的性能类似于或优于Depletion，但上级Optison（SonoVue的标准化散射功率高2至10倍）。在体内获得了类似的结果，尽管SonoVue在猪心脏中的增强持续时间长于Depletion，并且定量分析显示SonoVue的增强更高（增加1.5倍）。对于肝脏成像，SonoVue和Deadly表现出相似的对比度增强和增强持续时间，但与Optison相比，峰值增强和增强持续时间均上级SonoVue（高达2倍增加）。
ObjectivesTo compare physicochemical characteristics and in vitro and in vivo contrast-enhanced ultrasound imaging performance of 3 commercially available ultrasound contrast agents: SonoVue (Bracco Imaging SpA, Colleretto Giacosa, Italy; also marketed as Lumason in the USA), Definity (Lantheus Medical Imaging, North Billerica, MA) and Optison (GE Healthcare AS, Oslo, Norway).MethodsPhysicochemical characteristics were measured with a Multisizer Coulter Counter (Beckman Coulter, Fullerton, CA). Two ultrasound systems (Aplio 500; Toshiba Medical Systems Corp, Tochigi-ken, Japan; and Logiq E9; GE Healthcare, Little Chalfont, England) were used with different transducers. Contrast enhancement was measured in vitro by dose-ranging measurements using a custom-built beaker setup; in vivo imaging performances were compared in pigs (heart and liver) and rabbits (liver). Quantitative analyses were performed with VueBox quantification software (Bracco Suisse SA, Plan-les-Ouates, Switzerland).ResultsMeasured physicochemical characteristics were in agreement with those provided by the manufacturers. In vitro data demonstrated that the performance of SonoVue was similar to or better than that of Definity but superior to Optison (normalized scattered power 2- to 10-fold higher with SonoVue). Similar results were obtained in vivo, although the duration of enhancement in the pig heart was longer for SonoVue compared to Definity, and quantitative analysis revealed higher enhancement for SonoVue (1.5-fold increase). For liver imaging, SonoVue and Definity showed similar contrast enhancement and duration of enhancement, but compared to Optison, both peak enhancement and duration of enhancement were superior for SonoVue (up to 2-fold increase).ConclusionsImaging performance of SonoVue was similar to or slightly better than that of Definity, but it was superior to Optison for the conditions used in this study.