New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Proinflammatory Cytokine Inhibitory Activities
New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Proinflammatory Cytokine Inhibitory Activities
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DOI：
10.1515/znb-2010-0201
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发表时间：
2010-02
期刊：
影响因子：
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通讯作者：
R. Ren;X. Ci;Haizhou Li;G. Luo;Rong-Tao Li;Xu-ming Deng
中科院分区：
文献类型：
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作者：
R. Ren;X. Ci;Haizhou Li;G. Luo;Rong-Tao Li;Xu-ming Deng
通过对五味子果实的研究，分离到两种新的二苯并环二烯木脂素，甲基五味子素O(1)和氯甲基五味子素B(2)，以及12种已知的木脂素（3 ~ 14）。通过广泛的光谱技术，包括一维和二维核磁共振光谱，对它们的结构进行了分析。化合物2被鉴定为被氯甲基取代的环二烯部分，这在天然产物中很少发现，特别是在陆生高等植物中。在这些分离物中，化合物1和7对肿瘤坏死因子-α (TNF-α)和白细胞介素-6 （IL-6）的产生具有显著的抑制活性，对RAW264.7细胞没有任何细胞毒性。图示摘要：五味子中新的二苯并环七烯木脂素及其促炎细胞因子抑制活性
Investigation of the fruits of Schisandra sphenanthera led to the isolation of two new dibenzocyclooctadiene lignans, methylgomisin O (1) and chloromethyl schisantherin B (2), together with twelve known lignans (3 - 14). Their structures were elucidated by using extensive spectroscopic techniques including 1D and 2D NMR spectra. Compound 2 was identified as a cyclooctadiene moiety substituted with a chloromethyl group, which is rarely found in natural products, especially in terrestrial higher plants. Among these isolates, compounds 1 and 7 exhibited considerable inhibitory activity against tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) production, and did not display any cellular toxicity against RAW264.7 cells. Graphical Abstract New Dibenzocyclooctadiene Lignans from Schisandra sphenanthera and Their Proinflammatory Cytokine Inhibitory Activities