Effects of acute and repeated administration of N-methyl-D-aspartate (NMDA) into the ventral tegmental area: locomotor activating effects of NMDA and cocaine.
Effects of acute and repeated administration of N-methyl-D-aspartate (NMDA) into the ventral tegmental area: locomotor activating effects of NMDA and cocaine.
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急性和重复给予 N-甲基-D-天冬氨酸 (NMDA) 到腹侧被盖区的影响：NMDA 和可卡因的运动激活作用。
DOI：
10.1016/s0006-8993(97)00712-9
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发表时间：
1997
期刊：
影响因子：
2.9
通讯作者：
Partridge,B
中科院分区：
文献类型：
--
作者：
Schenk,S;Partridge,B
重复、间歇性地服用精神兴奋剂会增强这些药物随后的行为效应。这种行为敏感性与吸毒的维持和复发有关。因此，人们对阐明敏化的发展和表达背后的机制产生了极大的兴趣。兴奋剂诱导的运动活动研究数据的积累表明，兴奋性氨基酸与行为敏化的发展有关。在本研究中，将 N-甲基-d-天冬氨酸 (NMDA)（0.6、1.25 或 2.5 μg）双侧注入腹侧被盖区 (VTA)，产生剂量依赖性运动激活。重复施用 NMDA（两次暴露于 VTA 内 NMDA）后，NMDA 的运动激活作用增加，表明致敏。然而，重复的 VTA 内 NMDA 未能使大鼠对全身施用可卡因（5.0、10.0 或 20.0 mg/kg）的运动激活作用敏感。这些发现与 NMDA 受体的重复激活足以形成对 NMDA 行为敏感的观点是一致的。为了对这些药物的行为效应产生敏感性，需要重复施用精神兴奋剂产生其他神经适应。
Repeated, intermittent administration of psychostimulants produces an enhancement of the subsequent behavioral effects of these drugs. This behavioral sensitization has been implicated in maintenance of and relapse to drug-taking. As a result, there has been great interest in elucidating the mechanisms underlying both the development and expression of sensitization. An accumulation of data from studies of stimulant-induced locomotor activity has implicated excitatory amino acids in the development of behavioral sensitization. In the present study, N-methyl-d-aspartate (NMDA) (0.6, 1.25 or 2.5 μg) infused bilaterally into the ventral tegmental area (VTA) produced dose-dependent locomotor activation. The locomotor activating effect of NMDA was increased following repeated NMDA administration (two exposures to intra-VTA NMDA), suggesting sensitization. However, repeated intra-VTA NMDA failed to sensitize rats to the locomotor activating effects of systemically administered cocaine (5.0, 10.0 or 20.0 mg/kg). These findings are consistent with the notion that repeated activation of NMDA receptors is sufficient for the development of behavioral sensitization to NMDA. Other neuroadaptations produced by repeated psychostimulant administration are required in order for the development of sensitization to the behavioral effects of those drugs.
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DOI：
--
发表时间：
1974
期刊：
Philosophical transactions of the Royal Society of London. Series B, Biological sciences
影响因子：
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DOI：
10.1016/s0022-5347(17)45087-7
发表时间：
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期刊：
The Journal of urology
影响因子：
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作者：
C. Parsons
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