Constituents of chinese propolis and their antiproliferative activities
Constituents of chinese propolis and their antiproliferative activities
复制标题
DOI：
10.1021/np010486c
复制
发表时间：
2002-05-01
影响因子：
5.1
通讯作者：
Kadota, S
中科院分区：
文献类型：
--
作者：
Usia, T;Banskota, AH;Kadota, S
从中药茯苓的甲醇提取物的乙酸乙酯萃取部分中分离得到两个新的黄酮类化合物：3-O-[（S）-2-甲基丁酰基]松叶素（1）和6-肉桂叶树素（2），沿着12个已知化合物（3-14）。根据光谱和化学分析鉴定了分离的化合物的结构。测试了分离的化合物对五种不同癌细胞系的抗增殖活性。咖啡酸苄酯（13）和咖啡酸苯乙酯（14）对测试的细胞系显示出有效的抗增殖活性，对结肠26-L5癌细胞系具有选择性活性（EC 50值：13，1.01; 14，0.30 μ M）。
Two new flavonoids, 3-O-[(S)-2-methylbutyroyl]pinobanksin (1) and 6-cinnamylehrysin (2), were isolated from the EtOAc-soluble fraction of the MeOH extract of Chinese propolis, along with 12 known compounds (3-14). The structures of the isolated compounds were elucidated on the basis of spectroscopic and chemical analyses. The isolated compounds were tested for their antiproliferative activity toward five different cancer cell lines. Benzyl caffeate (13) and phenethyl caffeate (14) showed potent antiproliferative activity toward tested cell lines with a selective activity toward colon 26-L5 carcinoma cell line (EC50 values: 13, 1.01; 14, 0.30 muM).