Age is a critical risk factor for severe fever with thrombocytopenia syndrome.
Age is a critical risk factor for severe fever with thrombocytopenia syndrome.
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DOI：
10.1371/journal.pone.0111736
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发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Yu XJ
中科院分区：
文献类型：
--
作者：
Ding S;Niu G;Xu X;Li J;Zhang X;Yin H;Zhang N;Jiang X;Wang S;Liang M;Wang X;Yu XJ
严重发热伴血小板减少综合征(SFTS)是东亚地区的一种新发传染病。SFTS是由森林出血热病毒(SFTSV)引起的一种硬蜱传播的出血热，是一种以该综合征命名的新的布尼亚病毒。对山东省莱州市中国进行了流行性出血热的流行病学调查。收集2010年和2011年莱州市所有临床诊断为流行性出血热疑似病例的血清标本。用实时荧光定量聚合酶链式反应(RT-qPCR)检测患者血清标本中的SFTSV。2011年在莱州市随机抽取健康志愿者血清标本1060份。用酶联免疫吸附试验(ELISA)检测健康人血清标本中的特异性猪瘟病毒抗体。2010年和2011年莱州市共确诊流行性出血热71例，年发病率为4.1/10万。患者年龄15~87岁，中位年龄59岁。SFTS的发病率在40岁以上的患者明显较高，死亡病例仅发生在50岁以上的患者。33.3%(35/1060)的健康人血清中有SFTSV抗体阳性。不同年龄段人群间SFTSV抗体阳性率无显著差异。结果表明，莱州县健康人群中SFTSV的血清阳性率在不同年龄段之间无显著差异，但SFTS患者主要为老年人，提示年龄是SFTS发病率和死亡率的关键危险因素或决定因素。
Severe Fever with Thrombocytopenia Syndrome (SFTS) is an emerging infectious disease in East Asia. SFTS is a tick borne hemorrhagic fever caused by SFTSV, a new bunyavirus named after the syndrome. We investigated the epidemiology of SFTS in Laizhou County, Shandong Province, China. We collected serum specimens of all patients who were clinically diagnosed as suspected SFTS cases in 2010 and 2011 in Laizhou County. The patients' serum specimens were tested for SFTSV by real time fluorescence quantitative PCR (RT-qPCR). We collected 1,060 serum specimens from healthy human volunteers by random sampling in Laizhou County in 2011. Healthy persons' serum specimens were tested for specific SFTSV IgG antibody by ELISA. 71 SFTS cases were diagnosed in Laizhou County in 2010 and 2011, which resulted in the incidence rate of 4.1/100,000 annually. The patients ranged from 15 years old to 87 years old and the median age of the patients were 59 years old. The incidence rate of SFTS was significantly higher in patients over 40 years old and fatal cases only occurred in patients over 50 years old. 3.3% (35/1,060) of healthy people were positive to SFTSV IgG antibody. The SFTSV antibody positive rate was not significantly different among people at different age groups. Our results revealed that seroprevalence of SFTSV in healthy people in Laizhou County was not significantly different among age groups, but SFTS patients were mainly elderly people, suggesting that age is the critical risk factor or determinant for SFTS morbidity and mortality.
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影响因子：
11.8
作者：
Wen HL;Zhao L;Zhai S;Chi Y;Cui F;Wang D;Wang L;Wang Z;Wang Q;Zhang S;Liu Y;Yu H;Yu XJ
通讯作者：
Yu XJ
影响因子：
9.4
作者：
Jiao, Yongjun;Zeng, Xiaoyan;Wang, Hua
通讯作者：
Wang, Hua
影响因子：
11.8
作者：
Zhang, Yong-Zhen;He, Yong-Wen;Xu, Jianguo
通讯作者：
Xu, Jianguo
影响因子：
11.8
作者：
Bao, Chang-jun;Guo, Xi-ling;Wang, Hua
通讯作者：
Wang, Hua
中国一种新型布尼亚病毒引起的发热伴血小板减少症。
DOI：
10.1056/nejmoa1010095
发表时间：
2011-04-21
期刊：
The New England journal of medicine
影响因子：
--
作者：
Yu XJ;Liang MF;Zhang SY;Liu Y;Li JD;Sun YL;Zhang L;Zhang QF;Popov VL;Li C;Qu J;Li Q;Zhang YP;Hai R;Wu W;Wang Q;Zhan FX;Wang XJ;Kan B;Wang SW;Wan KL;Jing HQ;Lu JX;Yin WW;Zhou H;Guan XH;Liu JF;Bi ZQ;Liu GH;Ren J;Wang H;Zhao Z;Song JD;He JR;Wan T;Zhang JS;Fu XP;Sun LN;Dong XP;Feng ZJ;Yang WZ;Hong T;Zhang Y;Walker DH;Wang Y;Li DX
通讯作者：
Li DX