Search for endogenous ligands of the cannabinoid receptor.
Search for endogenous ligands of the cannabinoid receptor.
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寻找大麻素受体的内源配体。
DOI：
10.1016/0006-2952(94)90197-x
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发表时间：
1994
影响因子：
5.8
通讯作者：
Martin,BR
中科院分区：
文献类型：
--
作者：
Mechoulam,R;Hanus,L;Martin,BR
关于植物大麻素及其合成类似物及其临床效果的化学和药理学文献数量庞大且经过充分审查[l-4]。自从第一个大麻素受体和第一个内源性配体（anandamide）分别于 1988 年和 1992 年被描述以来 [5, 6]，关于它们的大量数据也积累了。然而，我们仍然对大麻素受体及其内源性配体在体内发挥的作用一无所知。在本综述中，我们描述了发现 anandamides 的道路及其生化和药理学特性；我们还推测它们的生理作用。
The literature in chemistry and pharmacology on plant cannabinoids and their synthetic analogs, and on their clinical effects, is vast and well reviewed [l-4]. Since the first cannabinoid receptor and the first endogenous ligand (anandamide) were described in 1988 and 1992, respectively [5, 6], a sizable amount of data on them has also accumulated. Yet, we still know nothing of the roles the cannabinoid receptors and their endogenous ligands play in the body. In the present review, we describe the road leading to the discovery of the anandamides, and their biochemical and pharmacological properties; we also speculate on their physiological roles.