Lethal Synergism between Influenza and Streptococcus pneumoniae.
Lethal Synergism between Influenza and Streptococcus pneumoniae.
复制标题
流感和肺炎链球菌之间的致命协同作用。
DOI：
10.16966/2470-3176.114
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发表时间：
2016-10
期刊：
影响因子：
--
通讯作者：
Teluguakula N
中科院分区：
文献类型：
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作者：
Rudd JM;Ashar HK;Chow VT;Teluguakula N
细菌性肺炎与流感病毒感染的毁灭性协同作用在上个世纪给世界留下了印记。尽管发病机制的细节仍不清楚，但协同作用与多种因素有关，包括暴露影响细菌粘附的受体的肺上皮屏障损伤以及引发过度的先天免疫应答和细胞因子风暴，其进一步加重损伤。正在讨论抗生素、抗炎药（包括皮质类固醇和toll样受体调节剂）和抗病毒药的几种治疗方法和联合治疗。这篇简短的综述总结了最近在发现流感后肺炎球菌合并感染的致命协同作用的发病机制方面的进展，以及目前正在评估的潜在治疗选择和治疗组合。
The devastating synergism of bacterial pneumonia with influenza viral infections left its mark on the world over the last century. Although the details of pathogenesis remain unclear, the synergism is related to a variety of factors including pulmonary epithelial barrier damage which exposes receptors that influence bacterial adherence and the triggering of an exaggerated innate immune response and cytokine storm, which further acts to worsen the injury. Several therapeutics and combination therapies of antibiotics, anti-inflammatories including corticosteroids and toll-like receptor modifiers, and anti-virals are being discussed. This mini review summarizes recent developments in unearthing the pathogenesis of the lethal synergism of pneumococcal co-infection following influenza, as well as addresses potential therapeutic options and combinations of therapies currently being evaluated.