Incredible RNA: Dual Functions of Coding and Noncoding.
Incredible RNA: Dual Functions of Coding and Noncoding.
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DOI：
10.14348/molcells.2016.0039
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发表时间：
2016-05-31
影响因子：
3.8
通讯作者：
You BH
中科院分区：
文献类型：
--
作者：
Nam JW;Choi SW;You BH
自RNA世界假说提出以来，从微生物到哺乳动物，许多物种中都发现了大量的调控性非编码RNA（ncRNA）。在这些新发现的RNA的表征过程中，发现了具有编码和非编码功能的RNA，这些RNA被认为是双功能RNA。最近使用的计算和高通量的实验方法已经揭示了越来越多的证据，各种来源的双功能RNA，如蛋白质编码的mRNA与非编码异构体和长ncRNA轴承一个小的开放阅读框架。因此，具有编码和非编码双重特征的Janus面RNA分子的基因组多样性表明RNA的功能作用必须在全基因组范围内重新审视。这些研究将使我们能够进一步了解细胞中复杂的基因调控网络。在这篇综述中，我们讨论了三个主要的基因组来源的双功能RNA，并提出了一些双功能RNA的例子沿着与他们的功能作用。
Since the RNA world hypothesis was proposed, a large number of regulatory noncoding RNAs (ncRNAs) have been identified in many species, ranging from microorganisms to mammals. During the characterization of these newly discovered RNAs, RNAs having both coding and noncoding functions were discovered, and these were considered bifunctional RNAs. The recent use of computational and high-throughput experimental approaches has revealed increasing evidence of various sources of bifunctional RNAs, such as protein-coding mRNAs with a noncoding isoform and long ncRNAs bearing a small open reading frame. Therefore, the genomic diversity of Janus-faced RNA molecules that have dual characteristics of coding and noncoding indicates that the functional roles of RNAs have to be revisited in cells on a genome-wide scale. Such studies would allow us to further understand the complex gene-regulatory network in cells. In this review, we discuss three major genomic sources of bifunctional RNAs and present a handful of examples of bifunctional RNA along with their functional roles.