Sustained exacerbation of cryoglobulinaemia-related vasculitis following treatment of hepatitis C with peginterferon alfa.
Sustained exacerbation of cryoglobulinaemia-related vasculitis following treatment of hepatitis C with peginterferon alfa.
复制标题
用聚乙二醇干扰素α治疗丙型肝炎后，冷球蛋白血症相关血管炎持续恶化。
DOI：
10.1097/01.meg.0000108342.41221.0c
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发表时间：
2004
影响因子：
2.1
通讯作者：
L. Weiss
中科院分区：
文献类型：
--
作者：
D. Batisse;M. Karmochkine;C. Jacquot;M. Kazatchkine;L. Weiss
聚乙二醇干扰素现在是治疗慢性丙型肝炎病毒感染患者的黄金标准。丙型肝炎的肝外表现通常用干扰素α治疗。在此，我们报告了一例丙型肝炎病毒相关性肝硬变和冷球蛋白血症患者，在使用聚乙二醇干扰素治疗期间，表现为急性和长期的血管炎加重。据我们所知，这是第一例使用聚乙二醇干扰素治疗丙型肝炎病毒相关性肝硬变患者的冷球蛋白血症相关血管炎急性加重的报告，该患者涉及皮肤、周围神经和肾脏。聚乙二醇干扰素的长半衰期可能解释了脉管炎的长期症状。临床医生应该意识到接受聚乙二醇干扰素治疗的患者可能会出现冷球蛋白血症相关性小血管炎的持续发作。
Peginterferon is now the gold standard of therapy in patients with chronic hepatitis C virus infection. Extrahepatic manifestations of HCV are usually treated with interferon alfa. Here we report on a patient with HCV-related cirrhosis and cryoglobulinaemia who presented with an acute and long-lasting exacerbation of vasculitis during treatment with peginterferon. To our knowledge this is the first report of an acute exacerbation of cryoglobulinaemia-related vasculitis involving skin, peripheral nerve and kidney in a patient treated with peginterferon for HCV-related cirrhosis. The long half-life of peginterferon might explain the long-lasting symptoms of vasculitis. Clinicians should be aware of possible sustained flare of cryoglobulinaemia-associated vasculitis in patients receiving peginterferon.