JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
JAK/STAT signaling in stem cells and regeneration: from Drosophila to vertebrates
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DOI：
10.1242/dev.167643
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发表时间：
2019-01-15
期刊：
影响因子：
4.6
通讯作者：
Bach, Erika A.
中科院分区：
文献类型：
--
作者：
Herrera, Salvador C.;Bach, Erika A.
JAK/STAT通路是一个保守的后生动物信号系统，它将细胞外细胞因子的信号转导到细胞核中的转录变化。JAK/STAT信号最为人所知的是它在免疫中的作用。然而，最近的研究表明，它也调节生殖细胞和体细胞干细胞的关键稳态过程，以及几种组织的再生过程，包括性腺、肠和附属物。在这里，我们概述了JAK/STAT信号在干细胞和再生中的作用，重点是果蝇，并强调了JAK/STAT信号通路在果蝇和脊椎动物之间保守的增殖、存活和细胞竞争中的作用。
The JAK/STAT pathway is a conserved metazoan signaling system that transduces cues from extracellular cytokines into transcriptional changes in the nucleus. JAK/STAT signaling is best known for its roles in immunity. However, recent work has demonstrated that it also regulates critical homeostatic processes in germline and somatic stem cells, as well as regenerative processes in several tissues, including the gonad, intestine and appendages. Here, we provide an overview of JAK/STAT signaling in stem cells and regeneration, focusing on Drosophila and highlighting JAK/STAT pathway functions in proliferation, survival and cell competition that are conserved between Drosophila and vertebrates.