Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
Anterior Segment Optical Coherence Tomography Angiography Imaging of Conjunctiva and Intrasclera in Treated Primary Open-Angle Glaucoma
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DOI：
10.1016/j.ajo.2019.05.008
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发表时间：
2019-12-01
影响因子：
4.2
通讯作者：
Tsujikawa, Akitaka
中科院分区：
文献类型：
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作者：
Akagi, Tadamichi;Uji, Akihito;Tsujikawa, Akitaka
目的：应用前段光学相干断层血管成像(AS-OCTA)研究青光眼患者的结膜和巩膜内血管，探讨AS-OCTA图像中血管密度的影响因素。设计：前瞻性横断面研究。方法：34例原发性开角型青光眼患者和20例正常人。使用扫描源OCT系统获得鼻象限和颞象限的角巩膜边缘的AS-OCTA图像。血管密度测量在浅层(从结膜上皮到200米深)和深层(从200到1000米深)。比较正常眼和青光眼的血管密度，并对可能的混杂因素进行单因素和多变量分析。结果：正常眼和青光眼的血管密度差异无统计学意义。在青光眼患者中，浅血管密度与前列腺素类似物的使用(P=.007)和鼻部位置(P=.016)显著相关。随着年龄的增长，青光眼的深层血管密度明显减小(P=0.029)，治疗后青光眼的深层血管密度明显增加(P=0.021)。结论：AS-OCTA图像有助于客观评价结膜充血，有助于了解小梁后房水流出的病理生理机制。((C)2019 Elsevier Inc.版权所有。)
PURPOSE: To investigate conjunctival and intrascleral vasculature in glaucoma eyes using anterior segment (AS)-optical coherence tomography angiography (OCTA) and assess the factors contributing to the vessel density in AS-OCTA images.DESIGN: Prospective, cross-sectional study.METHODS: Thirty-four patients with primary open angle glaucoma and 20 healthy subjects were included. A swept-source OCT system was used to obtain the AS-OCTA images of the corneoscleral limbus at the nasal and temporal quadrants. Vessel densities were measured in the superficial (from the conjunctival epithelium to a depth of 200 m) and deep (from a depth of 200 to 1000 pun) layers. The vessel density was compared between healthy and glaucoma eyes, and the associations of the vessel density with possible confounding factors were analyzed using univariable and multivariable analyses.RESULTS: The vessel density was not significantly different between healthy eyes and eyes with glaucoma. There was a significant association of superficial vessel density with the use of a prostaglandin analog (P = .007) and with nasal location (P = .016) in eyes with glaucoma. Deep vessel density was significantly smaller with advancing age (P = .029) in healthy eyes and greater with higher intra-ocular pressure (P = .021) in eyes with treated glaucoma.CONCLUSIONS: AS-OCTA images may be useful for the objective assessment of conjunctival hyperemia and helpful for understanding the pathophysiology of post-trabecular aqueous humor outflow. ((C) 2019 Elsevier Inc. All rights reserved.)