Decreases in Oral Tissue Blood Flow Induced by Remifentanil Are Not Accompanied by Deterioration of Oral Tissue Oxygen Tension in Rabbits
Decreases in Oral Tissue Blood Flow Induced by Remifentanil Are Not Accompanied by Deterioration of Oral Tissue Oxygen Tension in Rabbits
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DOI：
10.1016/j.joms.2018.12.033
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发表时间：
2019-05-01
影响因子：
1.9
通讯作者：
Ichinohe, Tatsuya
中科院分区：
文献类型：
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作者：
Kobayashi, Sayaka;Kasahara, Masataka;Ichinohe, Tatsuya
用途：本研究旨在观察瑞芬太尼对兔下颌骨骨髓和咬肌组织血流量和组织氧分压的影响。此外，在这些组织中的组织耗氧量的变化，在瑞芬太尼infrations.Materials和方法：16只日本白色雄性家兔气管切开，用七氟醚麻醉下机械通气。在氧气和空气吸入下，将吸入氧气的分数设定为0.4，并以0.4 μ g的速率输注瑞芬太尼。kg（-1）。最小值（-1）。在瑞芬太尼输注前、瑞芬太尼输注开始后20分钟、瑞芬太尼输注完成后20分钟和60分钟进行测量（n = 8）。观察指标包括心率（HR）、收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）、下颌骨骨髓组织血流量（BBF）、咬肌组织血流量（MBF）、下颌骨骨髓组织氧分压（PbO 2）和咬肌组织氧分压（PmO 2）。另取8只家兔，观察其下颌后静脉供血区动脉pH、乳酸、碱过剩（BE）和组织耗氧量。结果：瑞芬太尼输注过程中，HR、SBP、DBP、MAP、BBF、MBF均下降，而MAP、BBF、MBF均下降。在瑞芬太尼输注后20分钟，PbO 2升高，并在瑞芬太尼输注后60分钟恢复到几乎基线值。PMO 2在整个实验过程中没有变化。股动脉血氧含量与下颌后静脉血氧含量之差在瑞芬太尼输注期间减小。动脉pH值，乳酸，BE并没有改变remifentanilinfration.Conclusions：瑞芬太尼降低BBF和MBF，但没有降低PbO 2和PmO 2。提示瑞芬太尼输注过程中组织耗氧量降低。(C)2019年美国口腔颌面外科医师协会
Purpose: The purpose of this study was to investigate the effects of remifentanil infusion on tissue blood flow and tissue oxygen tension in the mandibular bone marrow and masseter muscle in rabbits. In addition, changes in tissue oxygen consumption in those tissues during remifentanil infusion were investigated.Materials and Methods: Sixteen male tracheotomized Japanese White rabbits were anesthetized with sevoflurane under mechanical ventilation. Under oxygen and air inhalation, fraction of inspiratory oxygen was set at 0.4 and remifentanil was infused at a rate of 0.4 mu g . kg(-1). min(-1). Measurements were performed before remifentanil infusion, 20 minutes after the start of remifentanil infusion, and 20 and 60 minutes after the completion of remifentanil infusion (n = 8). The observed variables included heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP), mandibular bone marrow tissue blood flow (BBF), masseter muscle tissue blood flow (MBF), mandibular bone marrow tissue oxygen tension (PbO2), and masseter muscle tissue oxygen tension (PmO2). Another 8 rabbits were observed for arterial pH, lactate, base excess (BE), and tissue oxygen consumption in the region from which the retromandibular vein received venous blood. Measurements were performed before remifentanil infusion and 20 minutes after the start of remifentanil infusion.Results: HR, SBP, DBP, MAP, BBF, and MBF decreased during remifentanil infusion. PbO2 increased 20 minutes after remifentanil infusion and returned to almost the baseline value 60 minutes after remifentanil infusion. PmO2 did not change throughout the experiment. The difference between the arterial oxygen content of the femoral artery and the venous oxygen content of the retromandibular vein decreased during remifentanil infusion. Arterial pH, lactate, and BE did not change during remifentanil infusion.Conclusions: Remifentanil decreased BBF and MBF but did not decrease PbO2 and PmO2. It is suggested that tissue oxygen consumption decreased during remifentanil infusion. (C) 2019 American Association of Oral and Maxillofacial Surgeons