SHORT-TERM POSTISCHEMIC HYPOPERFUSION IMPROVES RECOVERY OF PROTEIN-SYNTHESIS IN THE RAT-BRAIN CORTEX
SHORT-TERM POSTISCHEMIC HYPOPERFUSION IMPROVES RECOVERY OF PROTEIN-SYNTHESIS IN THE RAT-BRAIN CORTEX
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DOI：
10.1007/bf02960912
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发表时间：
1995-06-01
期刊：
影响因子：
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通讯作者：
MARSALA, J
中科院分区：
文献类型：
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作者：
BURDA, J;GOTTLIEB, M;MARSALA, J
一个无细胞的系统，从大鼠大脑皮层被用来跟踪蛋白质合成的变化后，缺血和再灌注（四血管闭塞）。本实验的重点是防止在缺血后再灌注的第一阶段通过短胚低灌注产生的自由氧自由基的剧烈爆发。缺血30 min后，再灌注前5 min释放一侧（右侧）颈动脉造成低灌注，持续30 min至3 d。通过这种方法获得的结果表明，低灌注脑的蛋白质合成机制的活性高于正常血容量的;左半球，这是对侧的直接血流在低灌注期间，表现出更好的结果比右半球。
A cell-free system from rat brain cortex was used to follow changes in protein synthesis after ischemia and reperfusion (four-vessel occlusion). The experiment was focused to prevent a violent burst of free oxygen radicals creation during the first period of postischemic reperfusion by short-Germ hypoperfusion. After 30 min of ischemia, the authors applied hypoperfusion produced by releasing one (right) carotid for the first 5 min of reperfusion lasting from 30 min to 3 d. Results obtained by this procedure show that the activity of protein synthesis machinery from hypoperfused brains is higher than normovolemic ones; the left hemisphere, which is contralateral to direct blood flow during hypoperfusion, shows better results than the right hemisphere.