Lateralization of the Arcuate Fasciculus from Childhood to Adulthood and its Relation to Cognitive Abilities in Children
Lateralization of the Arcuate Fasciculus from Childhood to Adulthood and its Relation to Cognitive Abilities in Children
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DOI：
10.1002/hbm.20779
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发表时间：
2009-11-01
影响因子：
4.8
通讯作者：
Beaulieu, Christian
中科院分区：
文献类型：
--
作者：
Lebel, Catherine;Beaulieu, Christian
弓状束是一个主要的白色物质束，参与语言处理，也多次涉及智力和推理任务。人类大脑中的语言在功能和结构方面都是偏侧的，而弓形束反映了这种不对称性，但对儿童和青少年的偏侧模式知之甚少。我们使用弥散张量成像（DTI）和纤维束成像检查弓状束偏侧在一个大的（n = 183）组健康的右利手志愿者，年龄在5-30岁;一个子集的68名儿童，年龄在5-13岁也进行了认知评估。在大多数受试者中，弓形束的各向异性分数和流线数在左半球均显著高于右半球，尽管有些受试者（10%）是右侧化的。年龄和性别对偏侧化的影响不显著。接受认知评估的儿童被分为三组：一个“只左”组，其中只有左侧的弓状束可以跟踪，左侧组，和右侧组。在皮博迪图片词汇测验（PPVT）和NEPSY语音加工任务上，各组间的成绩差异显著，左侧化儿童在PPVT上的成绩显著优于右侧化儿童，左侧化儿童在语音加工上的成绩显著优于右侧化儿童。总之，DTI纤维束成像显示了儿童、青少年和年轻人的弓状束偏侧化，并揭示了儿童结构性白色物质偏侧化与特定认知能力之间的关系。《脑图谱》30：3563-3573，2009年。(C)2009 Wiley-Liss，Inc.
The arcuate fasciculus is a major white matter tract involved in language processing that has also been repeatedly implicated in intelligence and reasoning tasks. Language in the human brain is lateralized in terms of both function and structure, and while the arcuate fasciculus reflects this asymmetry, its pattern of lateralization is poorly understood in children and adolescents. We used diffusion tensor imaging (DTI) and tractography to examine arcuate fasciculus lateralization in a large (n = 183) group of healthy right-handed volunteers aged 5-30 years; a subset of 68 children aged 5-13 years also underwent cognitive assessments. Fractional anisotropy and number of streamlines of the arcuate fasciculus were both significantly higher in the left hemisphere than the right hemisphere in most subjects, although some subjects (10%) were right lateralized. Age and gender effects on lateralization were not significant. Children receiving cognitive assessments were divided into three groups: a "left-only" group in whom only the left side of the arcuate fasciculus could be tracked, a left-lateralized group, and a right-lateralized group. Scores on the Peabody Picture Vocabulary Test (PPVT) and NEPSY Phonological Processing task differed significantly among groups, With left-only subjects outperforming the right-lateralized group on the PPVT, and the left-lateralized children scoring significantly better than the right-lateralized group on phonological processing. In summary, DTI tractography demonstrates leftward arcuate fasciculus lateralization in children, adolescents, and young adults and reveals a relationship between structural white matter lateralization and specific cognitive abilities in children. Hum Brain Mapp 30:3563-3573, 2009. (C) 2009 Wiley-Liss, Inc.