Tissue compatibility to different surfaces of dental implants: in vitro studies.
Tissue compatibility to different surfaces of dental implants: in vitro studies.
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DOI：
10.1097/00008505-199807040-00012
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发表时间：
1998-01-01
影响因子：
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通讯作者：
Keller, J C
中科院分区：
文献类型：
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作者：
Keller, J C
影响细胞和组织对牙种植体生物材料反应的因素具有典型的空间和时间特征。在空间上，牙种植体必须与骨组织形成界面，以维持生物力学稳定性，并与软组织形成界面，以预防可能导致种植体周围炎的微生物感染。关于宿主组织对植入材料的反应的知识体系正在发展，尽管这些反应的具体机制尚未完全了解。从时间的角度来看，植入后似乎发生了一系列涉及细胞附着、迁移和分化的事件。这些早期的伤口愈合反应似乎受到下垫种植体表面特性的显著影响。我们的实验室将注意力集中在第一个细胞事件上，即骨和种植体表面之间界面的细胞附着。体外原代细胞模型已被开发并用于研究材料选择（Ti, Ti- 6al - 4v，羟基磷灰石类涂层），表面形貌（光滑到粗糙）和表面化学（作为制备处理的功能）对植入物表面发生的细胞事件的影响。目前，我们认为未涂层的钛植入物和那些由磷酸钙或羟基磷灰石样涂层制成的植入物都能够支持初始细胞附着，尽管它们可能通过不同的和不完全理解的机制发生。宿主组织与植入体表面的初始相互作用仍然是长期接受的关键，如果要开发和临床使用新一代的组织工程装置，必须了解这些相互作用。
Factors affecting cell and tissue responses to dental implant biomaterials are typically characterized as spatial and temporal. Spatially, a dental implant must form an interface with both bone tissue for the development and maintenance of biomechanical stability and soft tissue for the prevention of microbial infection that can lead to peri-implantitis. There is a developing body of knowledge regarding the reactions of host tissues to implant materials, although the specific mechanisms by which these responses are not yet totally understood. From a temporal standpoint, there seems to be a sequence of events after placement of an implant that involves cell attachment, migration, and differentiation. These early wound healing responses appear to be influenced significantly by the properties of the underlying implant surface. Our laboratory has focused its attention on the first cellular event, i.e., cell attachment at the interface between bone and the implant surface. An in vitro primary cell model has been developed and used to study the influence of materials selection (Ti, Ti-6Al-4V, hydroxyapatite-like coatings), surface topography (smooth to rough), and surface chemistry (as a function of preparation treatments) on the cellular events that occur at implant surfaces. Currently, we believe that both uncoated Ti implants and those fabricated with calcium phosphate or hydroxyapatite-like coatings are capable of supporting initial cellular attachment, although they probably occur by different and incompletely understood mechanisms. The initial interactions of the host tissues with the implant surface remain key for long-term acceptance and must be understood if new generations of tissue engineered devices are to be developed and used clinically.