Gold(I)-Catalyzed Tandem Intramolecular Methoxylation/Double Aldol Condensation Strategy Yielding 2,2'-Spirobi[indene] Derivatives.
Gold(I)-Catalyzed Tandem Intramolecular Methoxylation/Double Aldol Condensation Strategy Yielding 2,2'-Spirobi[indene] Derivatives.
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DOI：
10.1021/acs.orglett.2c02653
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发表时间：
2022-09
期刊：
影响因子：
5.2
通讯作者：
Jingfu Zhang;Sen Zhang;Zhixing Ding;Anbin Hou;Jiayue Fu;Hongwei Su;Maosheng Cheng;B. Lin;Lu Yang;Yongxian Liu
中科院分区：
文献类型：
--
作者：
Jingfu Zhang;Sen Zhang;Zhixing Ding;Anbin Hou;Jiayue Fu;Hongwei Su;Maosheng Cheng;B. Lin;Lu Yang;Yongxian Liu
采用金催化的分子内甲氧基化/双羟醛缩合串联策略合成了2，2 '-螺[茚]衍生物。通过使用一批炔酮底物检查该串联反应的范围，揭示了该反应具有良好的官能团耐受性。提出了一种阳离子金（I）催化剂/质子酸催化的串联反应机理。
The syntheses of 2,2'-spirobi[indene] derivatives based on a gold(I)-catalyzed tandem strategy involving intramolecular methoxylation/double aldol condensation were achieved. Examination of the scope of this tandem reaction by using a batch of alkynone substrates disclosed that the reaction possessed a good functional group tolerance. A cationic gold(I) catalyst/protonic acid-catalyzed mechanism for this tandem reaction is proposed.