Participation of blood vessel cells in human adaptive immune responses.

Participation of blood vessel cells in human adaptive immune responses.
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DOI:
10.1016/j.it.2011.09.006
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发表时间:
2012-01
影响因子:
16.8
通讯作者:
Tellides G
Tellides G
中科院分区:
医学1区
文献类型:
--
作者:
Pober JS;Tellides G

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循环T细胞接触血管,当它们渗出穿过微血管壁进入发炎组织时,或者当它们进入炎性疾病如动脉粥样硬化的较大血管壁时。血管壁主要由三种细胞类型组成:衬在整个血管树上的内皮细胞、支持微血管内皮的周细胞和形成大血管壁的平滑肌细胞。这些细胞类型中的每一种都以不同的方式与浸润性T细胞相互作用并改变其行为,使这些细胞积极参与免疫介导的炎症过程。在这篇评论中,我们将比较和对比什么是已知的这些相互作用的性质在人类。
Circulating T cells contact blood vessels either when they extravasate across the walls of microvessels into inflamed tissues or when they enter into the walls of larger vessels in inflammatory diseases such as atherosclerosis. The blood vessel wall is largely composed of three cell types: endothelial cells lining the entire vascular tree, pericytes supporting the endothelium of microvessels and smooth muscle cells forming the bulk of large vessel walls. Each of these cell types interacts with and alters the behavior of infiltrating T cells in different ways, making these cells active participants in the processes of immune-mediated inflammation. In this review we will compare and contrast what is known about the nature of these interactions in humans.
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