Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line.
Intracellular accumulation of T-cell receptor complex molecules in a human T-cell line.
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人类 T 细胞系中 T 细胞受体复合物分子的细胞内积累。
DOI：
10.1126/science.3490690
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Wang,CY
中科院分区：
文献类型：
--
作者：
Tse,DB;Al-Haideri,M;Pernis,B;Cantor,CR;Wang,CY
这项工作旨在通过研究t细胞受体复合物的细胞分布和分子运输来了解t淋巴细胞功能的机制。胞浆内囊泡中特异性分子的积累与T淋巴细胞的活化有关。其中一些分子包括酸水解酶、转铁蛋白受体和主要组织相容性复合体的I类抗原。在来源于淋巴细胞白血病的人t细胞系的胞浆内囊泡中也发现了t细胞受体复合物的分子。这些囊泡与细胞质微管网络紧密相关。这种联系的一个功能方面是一个细胞途径，通过这个途径来往于细胞表面的囊泡聚集在一个富含加工酶的细胞区域。
This work was aimed at understanding the mechanisms of T-lymphocyte function by studying the cellular distribution and traffic of molecules of the T-cell receptor complex. The accumulation of specific molecules in intracytoplasmic vesicles is related to the activation of T lymphocytes. Some of these molecules include acid hydrolases, the transferrin receptor, and class I antigens of the major histocompatibility complex. Molecules of the T-cell receptor complex have now also been found in intracytoplasmic vesicles in a human T-cell line derived from a lymphoblastic leukemia. Such vesicles were tightly associated with the cytoplasmic microtubule network. One functional aspect of this association is a cellular pathway by which vesicles traveling to and from the cell surface converge in an area of the cells that is rich in processing enzymes.