Editorial for "Age-Related Changes in the Spatial Variation of Magnetic Susceptibility of Human Articular Cartilage".
Editorial for "Age-Related Changes in the Spatial Variation of Magnetic Susceptibility of Human Articular Cartilage".
复制标题
“人类关节软骨磁化率空间变化的年龄相关变化”的社论。
DOI：
10.1002/jmri.28512
复制
发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Jochimsen,KateN
中科院分区：
文献类型：
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作者：
Samaan,MichaelA;Jochimsen,KateN
衰老与关节软骨细胞组成的变化有关。 1 这些与年龄相关的软骨成分变化，加上关节负荷模式的改变，可能有助于解释老年人骨关节炎 (OA) 患病率的增加。 2 之前使用 T1rho（蛋白多糖含量）和 T2（胶原蛋白结构）图谱评估软骨成分的研究表明，与无症状的年轻人（18-44 岁）相比，无症状的老年人（≥ 45 岁）的软骨成分更差。 3-5 这表明定量磁共振成像 (QMRI) 足够灵敏，可以检测软骨成分中与年龄相关的变化3-5，但仍然很难确定软骨成分这些变化的主要贡献者。定量空间测绘 (QSM) 是一种测量软骨磁化率值的技术，并且对胶原纤维方向敏感。 6 健康软骨表现出特定的深度依赖性胶原纤维取向 7，这种天然胶原纤维取向为软骨提供了高拉伸刚度和强度。 8 衰老对关节软骨内胶原纤维取向的影响尚不清楚，因此需要进行评估，因为胶原纤维取向可能与老龄化人群中 OA 患病率的增加有关。
Aging is associated with changes in the cellular composition of articular cartilage. 1 These age-related changes in cartilage composition, combined with altered joint loading patterns, may help to explain the increased prevalence of osteoarthritis (OA) in older adults. 2 Prior work using T1rho (proteoglycan content) and T2 (collagen structure) mapping to assess cartilage composition demonstrated that asymptomatic, older adults (≥ 45 years) exhibit worse cartilage composition compared to asymptomatic, young adults (18–44 years). 3–5 This suggests that quantitative magnetic resonance imaging (QMRI) is sensitive enough to detect age-related changes in cartilage composition3–5 but it remains difficult to specify the primary contributor to these changes in cartilage composition.Quantitative spatial mapping (QSM) is a technique that measures the magnetic susceptibility value in cartilage and is sensitive to collagen fiber orientation. 6 Healthy cartilage exhibits a specific depth-dependent collagen fiber orientation7 and this natural collagen fiber orientation provides cartilage with its high tensile stiffness and strength. 8 The impact of aging on collagen fiber orientation within articular cartilage is not well understood and therefore, warrants assessment as collagen fiber orientation may be associated with the increased prevalence of OA in the aging population.