A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy
A comparison of cortical and trabecular bone from C57 Black 6 mice using Raman spectroscopy
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DOI：
10.1016/j.bone.2009.01.008
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发表时间：
2009-05-01
期刊：
影响因子：
4.1
通讯作者：
Aspden, Richard M.
中科院分区：
文献类型：
--
作者：
Goodyear, Simon R.;Gibson, Iain R.;Aspden, Richard M.
皮质骨和小梁骨都是由相同的细胞类型产生和维持的。在微观尺度上，它们具有相似的层状结构，但在宏观尺度上，它们非常不同。拉曼显微镜已被用于研究在两种骨类型的组成差异，使用标准的实验室小鼠在生理条件下的骨。当通过主成分分析（PCA）比较完整的光谱时，观察到明显的差异。单个条带的分析显示，与骨小梁材料相比，皮质骨具有老年骨的组成特征，可能是由于传统上报告的骨小梁室中的骨转换较高。(C)2009爱思唯尔公司All rights reserved.
Cortical and trabecular bone are both produced and maintained by the same cell types. At the microscopic scale they have a similar lamellar structure but at a macroscopic scale they are very different. Raman microscopy has been used to investigate compositional differences in the two bone types using bone from standard laboratory mice in physiological conditions. Clear differences were observed when complete spectra were compared by principal component analysis (PCA). Analysis of individual bands showed cortical bone to have compositional characteristics of older bone when compared with trabecular material, possibly due to the higher bone turnover traditionally reported in the trabecular compartment. (C) 2009 Elsevier Inc. All rights reserved.