QUANTITATIVE MR RELAXOMETRY STUDY OF MUSCLE COMPOSITION AND FUNCTION IN DUCHENNE MUSCULAR-DYSTROPHY
QUANTITATIVE MR RELAXOMETRY STUDY OF MUSCLE COMPOSITION AND FUNCTION IN DUCHENNE MUSCULAR-DYSTROPHY
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DOI：
10.1002/jmri.1880040113
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发表时间：
1994-01-01
期刊：
影响因子：
--
通讯作者：
MILLER, RG
中科院分区：
文献类型：
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作者：
HUANG, YM;MAJUMDAR, S;MILLER, RG
采用磁共振成像和T1、T2值图研究杜氏肌营养不良（DMD）患者的肌肉成分。健康对照组胫骨前肌平均T2为27 msec， DMD患者脂肪浸润增加，平均T2为43 msec。在较强的DMD患者中，肌肉T2值的分布较窄，与对照组一样以27 msec为中心，脂肪峰值以49 msec为中心，无重叠。在较弱的DMD患者中，肌肉T2峰的宽度增加，峰值向脂肪峰偏移。随着脂肪浸润的增加，平均肌肉T1从1.7秒下降到0.6秒。这些结果表明，定量的T1和T2图谱可用于评估肌肉状态和监测DMD进展。
Magnetic resonance imaging and maps of T1 and T2 values were used to study muscle composition in Duchenne muscular dystrophy (DMD). The mean T2 of anterior tibial muscle was 27 msec in healthy control subjects and 43 msec with increased fatty infiltration in DMD patients. In stronger DMD patients, the distribution of muscle T2 values was narrow, centered at 27 msec as in the controls, with a nonoverlapping fat peak centered at 49 msec. In weaker DMD patients, the width of the muscle T2 peak increased and the peak shifted toward the fat peak. Mean muscle T1 decreased from 1.7 to 0.6 second with increasing fatty infiltration. These results show that quantitative T1 and T2 maps may be used to assess muscle status and monitor DMD progression.