Combining cellular and gene therapy approaches for treatment of intracranial tumors.
Combining cellular and gene therapy approaches for treatment of intracranial tumors.
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DOI:
10.4161/onci.25989
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发表时间:
2013-10-01
期刊:
影响因子:
7.2
通讯作者:
Kruse CA
中科院分区:
文献类型:
--
作者:
Hickey MJ;Kasahara N;Mueller BM;Kruse CA
New treatments are needed for brain metastasis, which is associated with high morbidity and mortality. Two novel cellular and gene therapy modalities were evaluated in xenograft models for human breast cancer. The individual and especially the combined treatments with alloreactive cytotoxic T lymphocytes and replicating retroviral vectors coding for prodrug activating enzymes followed later with nontoxic prodrug demonstrated efficacy without off-target effects.
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DOI:
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发表时间:
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期刊:
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影响因子:
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期刊:
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