Is knowing the age-order of alleles in a sample useful in testing for selective neutrality?
Is knowing the age-order of alleles in a sample useful in testing for selective neutrality?
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了解样本中等位基因的年龄顺序对于测试选择性中性有用吗？
DOI：
10.1093/genetics/122.3.705
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发表时间：
1989
期刊：
影响因子：
3.3
通讯作者：
Joyce,P
中科院分区：
文献类型：
--
作者：
Tavaré,S;Ewens,WJ;Joyce,P
最有效和最常用的选择中性检验是G. A.沃特森该过程使用样本纯合性F* 作为检验统计量，如果F* 的观察值与中性理论预期显着不同，则实际上会导致拒绝选择性中性的假设。纯合性统计在等位基因的重新标记下是不变的，因此不能使用可能可用的关于等位基因的任何进一步信息。我们目前的结果表明，有关等位基因的年龄顺序的信息不能用来提供一个更强大的测试程序比沃特森。
The most powerful, and most frequently used, test of selective neutrality, based on data consisting of observed allelic frequencies in a sample of genes at some locus, is the procedure of G. A. Watterson. This procedure uses the sample homozygosity F* as the test statistic, and in effect leads to rejection of the hypothesis of selective neutrality if the observed value of F* differs significantly from neutral theory expectations. The homozygosity statistic is invariant under relabeling of the alleles and thus cannot use any further information on the alleles which might be available. We present results which suggest that information concerning the age order of the alleles cannot be used to provide a more powerful testing procedure than that of Watterson.