Novel Factor Xa Inhibitor for the Treatment of Cerebral Venous and Sinus Thrombosis First Experience in 7 Patients
Novel Factor Xa Inhibitor for the Treatment of Cerebral Venous and Sinus Thrombosis First Experience in 7 Patients
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DOI：
10.1161/strokeaha.114.006167
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发表时间：
2014-08-01
期刊：
影响因子：
8.3
通讯作者：
Nagel, Simon
中科院分区：
文献类型：
--
作者：
Geisbuesch, Christina;Richter, Daniel;Nagel, Simon
Background and Purpose-Thrombosis of cerebral veins and sinus (cerebral venous thrombosis) is a rare stroke pathogenesis. Pharmaceutical treatment is restricted to heparin and oral anticoagulation with vitamin K antagonists (VKAs).Methods-Between January 2012 and December 2013, we recorded data from our patients with cerebral venous thrombosis. The modified Rankin scale was used to assess clinical severity; excellent outcome was defined as modified Rankin scale 0 to 1. Recanalization was assessed on follow-up MR angiography. Patients were then divided into 2 treatment groups: phenprocoumon (VKA) and a novel factor Xa inhibitor. Clinical and radiological baseline data, outcome, recanalization status, and complications were retrospectively compared.Results-Sixteen patients were included, and 7 were treated with rivaroxaban. Overall outcome was excellent in 93.8%, and all patients showed at least partial recanalization. No statistical significant differences were found between the groups, except the use of heparin before start of oral anticoagulation (P=0.03). One patient in the VKA and 2 patients in the factor Xa inhibitor group had minor bleeding (P=0.55) within the median (range) follow-up of 8 months (5-26).Conclusions-Factor Xa inhibitor showed a similar clinical benefit as VKA in the treatment of cerebral venous thrombosis. Further systematic prospective evaluation is warranted.
