Prototype misidentification makes conclusions about pathotype growth characteristics uncertain.
Prototype misidentification makes conclusions about pathotype growth characteristics uncertain.
复制标题
原型错误识别使得关于致病型生长特征的结论不确定。
DOI：
10.1086/510399
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Dawson,ChandlerR
中科院分区：
文献类型：
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作者：
Schachter,Julius;Dawson,ChandlerR
对编辑-Miyairi等人[1]提出，他们对几个沙眼衣原体分离株的生长速度和发育周期的仔细测量可能反映了定义衣原体病型的基因组差异。为此目的，将分离株分为眼部菌株(地方性沙眼)和生殖器菌株(生殖道淋巴肉芽肿菌株和沙眼生物群菌株)。这种区分的有效性取决于对原型菌株的准确鉴定。不幸的是，在这种情况下，其中一个眼睛原型被错误地识别了。E/Bour分离株被描述为来自“一名地方性沙眼患者”(第351页)。事实上，患者已经在旧金山湾区生活了很多年[2]。虽然当时地方性沙眼在美国西南部印第安人中仍然流行，直到20世纪30年代在美国一直是地方性沙眼，但旧金山湾区在20世纪50年代并不是沙眼流行的地区。人们很早就知道生殖道的衣原体感染可以扩散到眼睛，在分娩过程中接触到沙眼的成年人或新生儿会引起包涵性结膜炎[3]。事实上，随着沙眼衣原体卵子分离的出现，20世纪60年代初在旧金山和伦敦进行的“包涵性结膜炎”研究开始揭示沙眼衣原体广泛存在于生殖道[4，5]。
To the Editor—Miyairi et al.[1] suggest that their careful measurements of growth rates and developmental cycles of several Chlamydia trachomatis isolates may reflect genomic differences that define chlamydial pathotypes. For their purposes, isolates were divided into ocular strains (endemic trachoma) versus genital strains (a lymphogranuloma venereum strain and trachoma biovar isolates from the genital tract). The validity of such differentiation depends on the accurate identification of prototype strains. Unfortunately, in this case, one of the ocular prototypes is misidentified. The E/Bour isolate is described as coming from “a patient with endemic trachoma”(p. 351). In fact, the patient had lived in the San Francisco Bay area for many years [2]. Although endemic trachoma was still prevalent among southwestern American Indians at that time and had been endemic in the United States into the 1930s, the San Francisco Bay area was not an area where trachoma was endemic in the 1950s.It had long been known that chlamydial infection of the genital tract could spread to the eye, causing inclusion conjunctivitis in adults or newborns exposed to the organism during delivery [3]. Indeed, with the advent of egg isolation for C. trachomatis, studies in the early 1960s of “inclusion conjunctivitis” in San Francisco and in London began to reveal the widespread genital-tract reservoir of C. trachomatis [4, 5].