Prevalence of cardiovascular risk factors and disease in people with schizophrenia: A population-based study
Prevalence of cardiovascular risk factors and disease in people with schizophrenia: A population-based study
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DOI：
10.1016/j.schres.2009.12.016
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发表时间：
2010-03-01
影响因子：
4.5
通讯作者：
Johnson, Jeffrey A.
中科院分区：
文献类型：
--
作者：
Bresee, Lauren C.;Majumdar, Sumit R.;Johnson, Jeffrey A.
目的：评价精神分裂症患者心血管危险因素（CV-RF）和疾病（CV-D）的患病率。方法：我们使用艾伯塔省行政数据库中基于人群的队列进行了一项时期患病率研究。使用账单代码识别精神分裂症；所有其他个体作为非精神分裂症对照。可改变的CV-RF（高血压、血脂异常、糖尿病）和已建立的CV-D（急性冠状动脉综合征（ACS）、慢性缺血性心脏病（IHD）、心力衰竭（HF）、中风、心律失常）采用先前验证的方法进行鉴定。采用多变量逻辑回归进行分析。结果：从1995年到2006年，28,755人（1.2%）被确定为精神分裂症，而非精神分裂症对照组为2,281,636人。与对照组相比，精神分裂症患者年龄较大（平均年龄47.6岁对45.3岁），社会经济地位较低（59%接受医疗补贴对21%:OR: 5.55: 95% CI: 5.42-5.69）。在CV-RF中，糖尿病在精神分裂症患者中比对照组更常见，特别是在年轻男性（30-39岁，3.8%对1.4%,aOR: 1.57; 95% CI: 1.30-1.91）和女性（30-39岁，5.8%对2.4%,aOR: 1.72; 95% CI: 1.44-2.04）中。精神分裂症患者的CV-D患病率明显高于对照组（27% vs. 17%, OR: 1.76; 95% CI: 1.72-1.81）。结论：在全国范围内，精神分裂症患者的糖尿病和心血管疾病患病率高于非精神分裂症患者，尤其是在年轻时。女性对精神分裂症患者的心血管没有保护作用。我们的数据表明，应该在精神分裂症诊断时就开始监测糖尿病和其他心血管危险因素，特别是对患有精神分裂症的女性。(C) 2009 Elsevier B.V.版权所有
Objective: To evaluate the prevalence of cardiovascular risk factors (CV-RF) and disease (CV-D) in people with schizophrenia.Method: We conducted a period-prevalence study using a population-based cohort from Alberta administrative databases. Schizophrenia was identified using billing codes; all other individuals served as non-schizophrenic controls. Modifiable CV-RF (hypertension, dyslipidemia, diabetes) and established CV-D (acute coronary syndrome (ACS), chronic ischemic heart disease (IHD), heart failure (HF), stroke, arrhythmia) were identified using previously validated methods. Analyses were conducted using multivariable logistic regression.Results: From 1995 to 2006, 28,755 people (1.2%) were identified with schizophrenia and compared with 2,281,636 non-schizophrenic controls. Individuals with schizophrenia were older (mean age 47.6 years vs. 45.3) and had lower socioeconomic status (59% received healthcare subsidies vs. 21%: OR: 5.55: 95% CI: 5.42-5.69) than controls. Of the CV-RF, diabetes was more common in those with schizophrenia than controls, particularly in younger males (ages 30-39, 3.8% vs. 1.4%, aOR: 1.57; 95% CI: 1.30-1.91) and females (ages 30-39, 5.8% vs. 2.4%, aOR: 1.72; 95% CI: 1.44-2.04). The prevalence of CV-D was significantly higher in people with schizophrenia than controls (27% vs. 17%, OR: 1.76; 95% CI: 1.72-1.81).Conclusions: On a population-wide basis, people with schizophrenia had a higher prevalence of diabetes and cardiovascular disease than those Without schizophrenia, particularly at a younger age. Female sex offered no cardiovascular protection in those with schizophrenia. Our data suggest monitoring for diabetes and other cardiovascular risk factors should begin at the time of diagnosis of schizophrenia, particularly in females with schizophrenia. (C) 2009 Elsevier B.V. All rights reserved.