Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata.
Dopamine D1 and D2 receptor selectivities of phenyl-benzazepines in rhesus monkey striata.
复制标题
恒河猴纹状体中苯基苯并氮杂卓的多巴胺 D1 和 D2 受体选择性。
DOI：
10.1016/s0014-2999(98)00669-4
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发表时间：
1998
影响因子：
5
通讯作者：
Paul,IA
中科院分区：
文献类型：
--
作者：
Weed,MR;Woolverton,WL;Paul,IA
Several phenyl-benzazepine compounds, putatively selective dopamine D1receptor agonists, have been used to study the effects of dopamine D1receptor stimulation in rodents and nonhuman primates. However, the dopamine receptor selectivities of these compounds have not been established in nonhuman primates. Accordingly, the relative selectivities of six phenyl-benzazepines for dopamine D1-like and D2-like receptors were assessed in rhesus monkey and, for comparison, rat striata. The compounds tested had higher affinity for D1than D2receptors in both species; however, their selectivity varied by up to three orders of magnitude. GTP (100 μM) reduced agonist binding at the high-affinity state of the dopamine D1receptor, but the magnitude of the effect of GTP did not reliably predict a compound's efficacy. Furthermore, a history of cocaine self-administration did not appear to influence dopamine receptor binding characteristics in the rhesus monkeys in this study. The present results will aid the comparison of dopamine receptor binding characteristics and behavioral effects of D1dopamine receptor agonists.
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多巴胺 D1 受体配体的激动剂功效和行为效应：松鼠猴的药物相互作用研究。
DOI：
--
发表时间：
1996
期刊：
The Journal of pharmacology and experimental therapeutics.
影响因子：
--
作者：
Bergman,J;Spealman,RD;Madras,BK;Rosenzweig-Lipson,S
通讯作者：
Rosenzweig-Lipson,S
DOI：
10.1016/0922-4106(90)90194-3
发表时间：
1990-06-12
期刊：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION
影响因子：
--
作者：
ANDERSEN, PH;JANSEN, JA
通讯作者：
JANSEN, JA
人重组多巴胺 D4 受体上多巴胺配体功能活性的表征
影响因子：
4.7
作者：
C. Chabert;Catherine Cavegn;Alain Bernard;A. Mills
通讯作者：
A. Mills
D1 多巴胺受体的立体异构探针：3-烯丙基-7,8-二羟基-1-苯基-2,3,4,5-四氢-1H-的 R-( ) 和 S-(-) 对映体的合成和表征
影响因子：
7.3
作者：
J. Neumeyer;N. Kula;R. Baldessarini;N. Baindur
通讯作者：
N. Baindur
多巴胺 D1 受体激动剂在大鼠、猴子和人类星形胶质细胞中表现出不同的内在活性。
影响因子：
5
作者：
R. Vermeulen;C. Jongenelen;C. Langeveld;E. Wolters;J. C. Stoof;B. Drukarch
通讯作者：
B. Drukarch