Salt discriminability is related to number of regenerated taste buds after chorda tympani nerve section in rats.
Salt discriminability is related to number of regenerated taste buds after chorda tympani nerve section in rats.
复制标题
盐辨别能力与大鼠鼓索神经切断后再生味蕾的数量有关。
DOI：
10.1152/ajpregu.1995.269.1.r141
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Spector,AC
中科院分区：
文献类型：
--
作者：
StJohn,SJ;Markison,S;Spector,AC
切断鼓索神经(CTX)可损害大鼠对氯化钠和氯化钾的味觉辨别能力。我们想确定这种辨别能力在鼓索再生后是否会恢复。实验1表明，CTX后14天几乎没有味蕾再生，而在手术后42天出现了大量的再生。实验2表明，在CTX之前训练的大鼠在手术后49天开始测试时可以清楚地区分这两种盐，而手术后8天开始测试的大鼠在这项任务中严重受损。从CTX后28天开始测试的大鼠在辨别任务中没有受损、中度受损或严重受损。总体而言，辨别能力与再生味蕾的数量显著相关。手术后不久测试的单侧横断的大鼠几乎和对照组一样有能力。这些结果表明，大鼠舌前味蕾再生后，可以恢复对氯化钠和氯化钾的辨别能力。
Transection of the chorda tympani nerve (CTX) impairs taste-guided discrimination of NaCl from KCl in rats. We wanted to determine whether this discrimination recovers after chorda tympani regeneration. Experiment 1 showed that few taste buds regenerated 14 days after CTX, whereas substantial regeneration occurred 42 days after surgery. Experiment 2 demonstrated that rats trained before CTX could clearly discriminate the two salts when tested starting 49 days after surgery, whereas rats tested starting 8 days after surgery were severely impaired in this task. Rats tested starting 28 days after CTX were unimpaired, moderately impaired, or severely impaired on the discrimination task. Overall, discrimination performance was significantly related to the number of regenerated taste buds. Unilaterally transected rats tested shortly after surgery were nearly as competent as controls. These results indicate that rats can recover the ability to discriminate NaCl from KCl after regeneration of anterior tongue taste buds.