Advances of Molecular Imaging for Monitoring the Anatomical and Functional Architecture of the Olfactory System.
Advances of Molecular Imaging for Monitoring the Anatomical and Functional Architecture of the Olfactory System.
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DOI：
10.1021/acschemneuro.5b00264
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发表时间：
2016-01
影响因子：
5
通讯作者：
Xintong Zhang;Anyao Bi;Quansheng Gao;Shuai Zhang;K. Huang;Zhiguo Liu;Tang Gao;Wenbin Zeng
中科院分区：
文献类型：
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作者：
Xintong Zhang;Anyao Bi;Quansheng Gao;Shuai Zhang;K. Huang;Zhiguo Liu;Tang Gao;Wenbin Zeng
生物体的嗅觉系统是研究感官输入如何转化为行为输出的遗传和解剖学模型。一些神经系统疾病被认为与嗅觉障碍有关，特别是阿尔茨海默病、帕金森病、多发性硬化症等。然而，嗅觉系统如何影响疾病产生过程和嗅觉传递过程仍不清楚。分子影像学是一门多学科的现代技术，它可以为疾病的早期检测和表征、治疗的评价以及活体生物学过程的研究提供有效的工具，因为分子影像学应用特定的分子探针作为一种新的方法来产生特殊的数据来研究细胞和亚细胞水平的生物学过程。近年来，分子影像学在研究嗅觉系统的激活方面发挥了重要作用，从而有助于预防或延缓某些疾病的发生。本文从PET、MRI、光学成像等不同成像方式对嗅觉系统成像探针的研究进展进行综述。此外，还对探针的设计、传感机理和生物学应用进行了讨论。最后，我们对该领域的未来研究进行了展望。
The olfactory system of organisms serves as a genetically and anatomically model for studying how sensory input can be translated into behavior output. Some neurologic diseases are considered to be related to olfactory disturbance, especially Alzheimer's disease, Parkinson's disease, multiple sclerosis, and so forth. However, it is still unclear how the olfactory system affects disease generation processes and olfaction delivery processes. Molecular imaging, a modern multidisciplinary technology, can provide valid tools for the early detection and characterization of diseases, evaluation of treatment, and study of biological processes in living subjects, since molecular imaging applies specific molecular probes as a novel approach to produce special data to study biological processes in cellular and subcellular levels. Recently, molecular imaging plays a key role in studying the activation of olfactory system, thus it could help to prevent or delay some diseases. Herein, we present a comprehensive review on the research progress of the imaging probes for visualizing olfactory system, which is classified on different imaging modalities, including PET, MRI, and optical imaging. Additionally, the probes' design, sensing mechanism, and biological application are discussed. Finally, we provide an outlook for future studies in this field.