The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor.
The CXC chemokines IP-10 and Mig are necessary for IL-12-mediated regression of the mouse RENCA tumor.
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DOI：
10.4049/jimmunol.161.2.927
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发表时间：
1998-07
影响因子：
4.4
通讯作者：
C. Tannenbaum;R. Tubbs;D. Armstrong;J. Finke;R. Bukowski;T. Hamilton
中科院分区：
文献类型：
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作者：
C. Tannenbaum;R. Tubbs;D. Armstrong;J. Finke;R. Bukowski;T. Hamilton
在携带鼠肾腺癌RENCA的小鼠中检查了不含ELR的CXC趋化因子IP-10和Mig在用IL-12全身治疗诱导的抗肿瘤活性中的作用。IL-12治疗产生与CD 8 + T淋巴细胞的肿瘤浸润相关的强效抗肿瘤作用。肿瘤的消退与肿瘤组织内IFN-γ诱导型趋化因子IP-10和Mig的表达升高相关。IP-10和Mig已被证明作为活化的T淋巴细胞的化学引诱剂。在用IP-10和Mig特异性兔多克隆抗体处理的动物中，IL-12诱导的RENCA肿瘤消退部分消除。这种作用与T细胞浸润的显著抑制有关。因此，似乎IL-12依赖性T细胞介导的抗肿瘤活性需要IP-10和Mig的中间表达以将抗肿瘤效应T细胞募集到肿瘤部位。
The role of the non-ELR-containing CXC chemokines IP-10 and Mig in antitumor activity induced by systemic treatment with IL-12 was examined in mice bearing the murine renal adenocarcinoma RENCA. IL-12 treatment produces a potent antitumor effect that is associated with tumor infiltration by CD8+ T lymphocytes. The regression of tumor is associated with the elevated expression of the IFN-gamma-inducible chemokines IP-10 and Mig within the tumor tissue. IP-10 and Mig have been shown to function as chemoattractants for activated T lymphocytes. In animals treated with rabbit polyclonal Abs specific for IP-10 and for Mig, the IL-12-induced regression of RENCA tumors was partially abrogated. This effect was associated with a dramatic inhibition of T cell infiltration. Thus, it appears that IL-12-dependent, T cell-mediated antitumor activity requires the intermediate expression of IP-10 and Mig to recruit antitumor effector T cells to the tumor site.