A COMPREHENSIVE REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM

A COMPREHENSIVE REVIEW ON GASTRO RETENTIVE DRUG DELIVERY SYSTEM
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胃滞留给药系统的全面综述

DOI：
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发表时间：
2013
期刊：
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影响因子：
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通讯作者：
Deepthi Poloju
Deepthi Poloju
中科院分区：
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文献类型：
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作者：
M. Kumar;B. Satyanarayana;Nagakanyaka Devi Paladugu;Neerukondavamsi;Sheik Muddasar;Shaik Irfan Pasha;ana Vemireddy;Deepthi Poloju

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近年来，口服给药系统的研究和开发取得了一些进展。新型给药系统的概念是为了克服药物分子和相关制剂的某些物理化学性质而产生的。本综述的目的是汇编最近的文献，特别侧重于各种胃滞留的方法，最近已成为领先的方法，在该领域的网站特定的口服给药控释药物输送。为了了解胃潴留的生理困难，我们总结了影响胃潴留的因素，并介绍了胃潴留的各种策略。GRDDS已成为口服局部给药控释系统的主要方法。利用该技术可以开发在碱性pH下不稳定、在酸性pH下可溶、吸收窗口窄、作用部位特异于胃的各种药物。
In recent years several advancements has been made in research and development of oral drug delivery system. Concept of novel drug delivery system arose to overcome certain aspect related to physicochemical properties of drug molecule and the related formulations. Purpose of this review is to compile the recent literature with special focus on various gastro retentive approaches that have recently become leading methodologies in the field of site-specific orally administered controlled release drug delivery. In order to understand various physiological difficulties to achieve gastric retention, we have summarized factors influencing gastric retention and also included various strategies for gastric retention. GRDDS has become leading methodology in site specific orally administered controlled release drug delivery system. Various drugs, which are unstable in alkaline pH, soluble in acidic pH, having narrow absorption window, site of action specific to stomach can be developed by using this technique.