Patients with cutaneous lupus erythematosus who smoke are less responsive to antimalarial treatment
Patients with cutaneous lupus erythematosus who smoke are less responsive to antimalarial treatment
复制标题
DOI：
10.1016/s0190-9622(00)90290-1
复制
发表时间：
2000-06-01
影响因子：
13.8
通讯作者：
McCauliffe, DP
中科院分区：
文献类型：
--
作者：
Jewell, ML;McCauliffe, DP
背景资料：报告表明，吸烟可能会干扰抗疟治疗作为皮肤红斑狼疮一线治疗的有效性。目的：探讨吸烟对盘状红斑狼疮（DLE）和亚急性皮肤红斑狼疮（SCLE）患者抗疟药物治疗反应的影响。方法：对61例DLE和SCLE患者进行吸烟治疗，观察吸烟对DLE和SCLE治疗反应的影响。根据以下标准选择了47例DLE，14例SCLE：（1）皮肤活检与皮肤LE一致，（2）有吸烟史，（3）完成了充分的抗疟治疗试验。根据患者病历中的描述，将患者分为抗疟药应答者或无应答者。对吸烟者和不吸烟者的应答率进行二乘二表分析。
Background: Reports suggest that cigarette smoking might interfere with the effectiveness of antimalarial therapy as first-line treatment for cutaneous lupus erythematosus. Patients refractory to this treatment often must be treated with potentially more toxic regimens.Objective: Our purpose was to examine the effects of cigarette smoking on the therapeutic response to antimalarial agents in patients with discoid lupus erythematosus (DLE) and subacute cutaneous lupus erythematosus (SCLE).Methods: A total of 61 patients (47 DLE, 14 SCLE) were selected on the basis of the following criteria: (1) skin biopsy was consistent with cutaneous LE, (2) a smoking history was available, and (3) an adequate trial of antimalarial therapy was completed. Patients were classified as antimalarial responders or nonresponders on the basis of descriptions in their medical records. Two-by-two table analysis was performed comparing response rates in smokers versus nonsmokers.Results: A significant difference (P