Rheology of sickle cells and the microcirculation.
Rheology of sickle cells and the microcirculation.
复制标题
镰状细胞的流变学和微循环。
DOI:
10.1056/nejm198412133112409
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发表时间:
1984
期刊:
影响因子:
--
通讯作者:
S. Chien
中科院分区:
文献类型:
--
作者:
S. Chien
IN homozygous sickle-cell disease, deoxygenation of red cells causes the polymerization of hemoglobin S and transformation of the intracellular fluid into a viscoelastic gel. This process is most prominent in particularly dense red cells that have a high concentration of hemoglobin S. The membrane of these dense red cells also has elevated viscoelastic moduli,1 , 2 probably as a result of mechanical stresses exerted during sickle–unsickle cycles. Therefore, the densest cells are most rigid and have the greatest effect on resistance3 in blood flow through the microcirculation. Studies of the retina of patients with sickle-cell disease4 and the microcirculation of animals receiving . . .
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影响因子:
1.1
作者:
Skalak,R;Impelluso,T;Schmalzer,EA;Chien,S
通讯作者:
Chien,S
影响因子:
20.3
作者:
G. Nash;C. Johnson;H. Meiselman
通讯作者:
G. Nash;C. Johnson;H. Meiselman
DOI:
--
发表时间:
1982
期刊:
Blood cells
影响因子:
--
作者:
Lipowsky,HH;Usami,S;Chien,S
通讯作者:
Chien,S
影响因子:
15.9
作者:
EVANS, E;MOHANDAS, N;LEUNG, A
通讯作者:
LEUNG, A