Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.
Genotype Arg/Arg, but not Trp/Arg, of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor is associated with type 2 diabetes and obesity in a large Japanese sample.
复制标题
在大量日本样本中，β(3)-肾上腺素能受体 Trp64Arg 多态性的基因型 Arg/Arg（而非 Trp/Arg）与 2 型糖尿病和肥胖相关。
作者：
T. Oizumi;M. Daimon;T. Saitoh;W. Kameda;H. Yamaguchi;H. Ohnuma;M. Igarashi;H. Eguchi;H. Manaka;M. Tominaga;T. Kato
客观的
尽管进行了大量研究，但尚未明确阐明β（3） - 肾上腺素能受体基因的TRP64ARG多态性（3） - 肾上腺素能受体基因。我们检查了大型基于人群的样本中的关联。
研究设计和方法
根据基因型，共有1,685名受试者（935名女性和750名男性，年龄在58.7岁+/- 12.4岁）中（n = 3,706）研究分为三组。 ），trp/arg（n = 486）和arg/arg（n = 44）。根据1985年世界卫生组织的标准诊断出葡萄糖耐受性。具有BMI>或= 30 kg/m（2）的受试者被认为是肥胖的。还检查了与肥胖，糖尿病，高血压和血脂异常有关的特征的关联。 CHI（2）测试和方差分析用于关联研究，并分别评估性状值的差异。
结果
与具有基因型TRP/TRP（3.29％，P <0.001;和4.16％，P = 0.007）或基因型TRP/ARG（2.06）相比，具有基因型ARG/ARG的受试者是肥胖和糖尿病（每个受试者13.6％）（每个受试者13.6％）。 ％，p <0.001和5.97％，p = 0.051）。在基因型TRP/ARG和TRP/TRP之间，在这些条件的发生频率上没有显着差异。与肥胖有关的特征，例如体内脂肪百分比（28.82 +/- 7.95 vs. 25.93 +/- 7.21，p = 0.038）和BMI（25.07 +/- 3.84 vs. 23.63 +/- 3.18，p = 0.018），he基因型ARG/ARG中的基因型TRP/TRP组高。
结论
β（3） - 肾上腺素受体的基因型ARG/ARG，而不是TRP/ARG，在一个大型日本样本中与肥胖和2型糖尿病都相关。
OBJECTIVE
Despite a large number of studies, no association of the Trp64Arg polymorphism of the beta(3)-adrenergic receptor gene with obesity and type 2 diabetes has yet to be clearly elucidated. We examined the associations in a large population-based sample.
RESEARCH DESIGN AND METHODS
A total of 1,685 subjects (935 women and 750 men, aged 58.7 +/- 12.4 years) from a cohort population (n = 3,706) of the Funagata Diabetes Study were divided into three groups according to genotypes: Trp/Trp (n = 1,155), Trp/Arg (n = 486), and Arg/Arg (n = 44). Glucose tolerance was diagnosed according to the 1985 World Health Organization criteria. Subjects who had a BMI > or =30 kg/m(2) were considered obese. Associations with the traits related to obesity, diabetes, hypertension, and dyslipidemia were also examined. The chi(2) test and analysis of variance were used for the association studies and to assess the differences in the traits' values, respectively.
RESULTS
More subjects with genotype Arg/Arg were obese and had diabetes (13.6% for each) than those with genotype Trp/Trp (3.29%, P < 0.001; and 4.16%, P = 0.007, respectively) or genotype Trp/Arg (2.06%, P < 0.001; and 5.97%, P = 0.051, respectively). No significant differences in the frequencies of occurrence of these conditions were observed between genotypes Trp/Arg and Trp/Trp. Traits related to obesity, such as percent body fat (28.82 +/- 7.95 vs. 25.93 +/- 7.21, P = 0.038) and BMI (25.07 +/- 3.84 vs. 23.63 +/- 3.18, P = 0.018), were higher in the genotype Arg/Arg than in the genotype Trp/Trp groups.
CONCLUSIONS
Genotype Arg/Arg, but not Trp/Arg, of the beta(3)-adrenergic receptor was associated with both obesity and type 2 diabetes in a large Japanese sample.
影响因子：
158.5
作者：
WALSTON, J;SILVER, K;SHULDINER, AR
通讯作者：
SHULDINER, AR
β3-肾上腺素能受体基因座在有糖尿病兄弟姐妹的白人家庭成员肥胖和非胰岛素依赖型糖尿病中的作用。
DOI：
10.1210/jcem.81.12.8954053
发表时间：
1996
期刊：
The Journal of clinical endocrinology and metabolism.
影响因子：
--
作者：
Elbein,SC;Hoffman,M;Barrett,K;Wegner,K;Miles,C;Bachman,K;Berkowitz,D;Shuldiner,AR;Leppert,MF;Hasstedt,S
通讯作者：
Hasstedt,S