A COMPARISON OF CLINICAL AND PATHOLOGICAL FEATURES OF YOUNG-ONSET AND OLD-ONSET PARKINSONS-DISEASE
A COMPARISON OF CLINICAL AND PATHOLOGICAL FEATURES OF YOUNG-ONSET AND OLD-ONSET PARKINSONS-DISEASE
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DOI：
10.1212/wnl.38.9.1402
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发表时间：
1988-09-01
期刊：
影响因子：
9.9
通讯作者：
LEES, AJ
中科院分区：
文献类型：
--
作者：
GIBB, WRG;LEES, AJ
我们比较了 46 名 45 岁之前发病的帕金森病患者和 52 名 70 岁之后发病的患者。年轻发病的病例更常表现为肌肉僵硬 (43%)，老年发病的病例更常出现行走困难 (33%)。三分之一的年轻发病病例有休期肌张力障碍，主要影响腿部，但老年发病病例中没有记录到肌张力障碍。 41% 的年轻发病者和 63% 的老年发病者出现静止性震颤。受影响的亲属数量、内分泌疾病、人格特征、痴呆或运动障碍没有差异。对 12 例年轻发病病例和 22 例老年发病病例进行的病理学研究显示，年轻发病病例的黑质细胞损失增加了 24%，但基本路易体病理学没有差异。年轻病例的中位病程在临床研究中延长了 5 年，在病理研究中延长了 12 年。这些研究表明，年轻和老年发病病例的帕金森病过程相似。
We compared 46 patients having onset of Parkinson''s disease before age 45 years with 52 haivng onset after age 70. Young-onset cases more often presented with muscular stiffness (43%) and old-onset with difficulty walking (33%). One-third of young-onset cases had off-period dystonia, mostly affecting the legs, but no dystonia was recorded in old-onset cases. Presentation with rest tremor occurred in 41% of young-onset and 63% of old-onset. There were no differences in the number of affected relatives, endocrine disease, personality characteristics, dementia, or dyskinesia. A pathological study of 12 young-onset and 22 old-onset cases showed 24% greater nigral cell loss in the young, but no differences in the basic Lewy body pathology. Median disease duration in young cases was 5 years longer in the clinical study and 12 years longer in the pathological study. These studies show that the Parkinson''s disease process in similar in young- and old-onset cases.