DENGUE HEMORRHAGIC-FEVER IN CUBA, 1981 - A RETROSPECTIVE SEROEPIDEMIOLOGIC STUDY
DENGUE HEMORRHAGIC-FEVER IN CUBA, 1981 - A RETROSPECTIVE SEROEPIDEMIOLOGIC STUDY
复制标题
DOI：
10.4269/ajtmh.1990.42.179
复制
发表时间：
1990-02-01
影响因子：
3.3
通讯作者：
MORIER, L
中科院分区：
文献类型：
--
作者：
GUZMAN, MG;KOURI, GP;MORIER, L
在古巴，发生了两次登革热病毒流行：1977年由DEN-1引起的一次和1981年由DEN-2引起的一次。后者与登革出血热/登革休克综合征（DHF/DSS）病例有关。为了研究DHF/DSS的病毒危险因素，在哈瓦那市人口稠密的Cerro区进行了回顾性血清流行病学调查。在1，295名个体（儿童和成人）中测量了DEN-1和DEN-2病毒的空斑减少中和抗体的患病率。登革1型病毒免疫率为43.7%，登革2型病毒免疫率为23.6%。在免疫的人中，26.1%只对DEN-1病毒免疫，6%只对DEN-2病毒免疫，17.6%对两种病毒都免疫。登革1型免疫者的登革2型病毒感染率是未免疫者的3.8倍。样本中的5例DHF/DSS病例有DEN-1病毒加DEN-2病毒感染的证据。其中3人是儿童，2人是年轻人。在仅感染DEN-1病毒或DEN-2病毒的个体中未发现病例。登革1型病毒感染后再感染登革2型病毒的儿童患登革出血热/DSS的风险高。黑人和白人同样感染DEN-1和DEN-2病毒。
In Cuba, 2 epidemics of dengue virus occurred: 1 caused by DEN-1 in 1977 and 1 caused by DEN-2 in 1981. The latter was associated with cases of dengue hemorrhagic fever/dengue shock syndrome (DHF/DSS). To study viral risk factors for DHF/DSS, a retrospective seroepidemiological survey was conducted in Cerro, a densely populated district in Havana City. The prevalence of plaque reduction neutralizing antibodies to DEN-1 and DEN-2 viruses was measured in 1,295 individuals (children and adults). Of these, 43.7% were immune to DEN-1 virus and 23.6% to DEN-2 virus. Of those individuals who were immune, 26.1% were immune to DEN-1 virus only, 6% to DEN-2 virus only, and 17.6% to both viruses. The DEN-2 virus infection rate in DEN-1 immune individuals was 3.8 times higher than in non-immune individuals. The 5 DHF/DSS cases in the sample had evidence of DEN-1 virus plus DEN-2 virus infections. Three were children and 2 were young adults. No cases were found in individuals infected with DEN-1 virus or DEN-2 virus only. Children infected by DEN-1 virus followed by DEN-2 virus had a high risk of acquiring DHF/DSS. Blacks and whites were equally infected with DEN-1 and DEN-2 viruses.