The Influence of Tilt, Decentration, and Pupil Size on the Higher-Order Aberration Profile of Aspheric Intraocular Lenses
The Influence of Tilt, Decentration, and Pupil Size on the Higher-Order Aberration Profile of Aspheric Intraocular Lenses
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DOI：
10.1016/j.ophtha.2011.02.025
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发表时间：
2011-09-01
期刊：
影响因子：
13.7
通讯作者：
McGhee, Charles
中科院分区：
文献类型：
--
作者：
McKelvie, James;McArdle, Brian;McGhee, Charles
目的：使用物理模型眼表征倾斜角、偏心和瞳孔大小对 3 个非球面人工晶状体 (IOL) 高阶像差 (HOA) 轮廓的影响。设计：使用物理模型眼比较 3 个非球面人工晶状体的 4 因素（模型、瞳孔、角度、偏心）体外实验设计。方法：使用 Zywave 像差计（博士伦，罗切斯特， NY）和专门建造的物理模型眼睛。以下人工晶体通过瞳孔直径、偏心和倾斜角的不同水平和组合进行评估：AcrySof IQ SN60WF 非球面镜片（Alcon，Hunenberg，瑞士）、Technis ZA9003 非球面镜片（Advanced Medical Optics，圣安娜，加利福尼亚州）和 Adapt Advanced Optics（博士伦）。使用多变量方差分析、典型判别和回归分析对 15 种 Zernike 模式进行了比较。每个 IOL 模型的四个相同的 IOL 在 3 个瞳孔大小、4 个偏心水平和 4 个倾斜角度的所有可能组合下进行评估。主要结果测量：从 z200 到 z550 的个体 HOA。结果：瞳孔大小、偏心、模型和倾斜角度都对 HOA 轮廓具有静态显着影响。瞳孔大小对观察到的总变异性贡献最大（54.9％），其次是偏心（22.7％），然后是模型（16.6％），最后是倾斜角度（5.7％）。所有因素都表现出与 HOA 相关的显着交互项。光学设计中固有的非球面特性增强的人工晶状体对偏心和瞳孔大小的变化更加敏感。结论：3 个 IOL 模型显示 HOA 在响应瞳孔大小、偏心和倾斜角度的变化方面存在显着差异。本研究中评估的所有 IOL 模型均在小瞳孔直径下显示出最小的 HOA。具有较低或不存在负球面像差的 IOL 模型对于随着偏心和倾斜角增加而产生的位移最为稳健。
Purpose: To characterize the influence of tilt angle, decentration, and pupil size on the higher-order aberration (HOA) profile of 3 aspheric intraocular lenses (IOLs) using a physical model eye.Design: A 4-factor (model, pupil, angle, decentration) in vitro experimental design comparing 3 aspheric IOLs using a physical model eye.Methods: Measurements of HOA were obtained using the Zywave aberrometer (Bausch & Lomb, Rochester, NY) and a purpose-built physical model eye. The following IOLs were assessed with various levels and combinations of pupil diameter, decentration, and tilt angle: the AcrySof IQ SN60WF aspheric (Alcon, Hunenberg, Switzerland), Technis ZA9003 aspheric (Advanced Medical Optics, Santa Ana, CA), and Adapt Advanced Optics (Bausch & Lomb). Fifteen Zernike modes were compared using multivariate analysis of variance, canonical discrimination, and regression analysis. Four identical IOLs of each IOL model were assessed at all possible combinations of 3 pupil sizes, 4 levels of decentration, and 4 tilt angles.Main Outcome Measures: Individual HOA from z200 to z550.Results: Pupil size, decentration, model, and tilt angle all had statically significant effects on the HOA profile. Pupil size contributed most to observed total variability (54.9%), followed by decentration (22.7%), then model (16.6%), and finally tilt angle (5.7%). All factors demonstrated significant interaction terms with respect to HOA. Intraocular lenses with increased aspheric properties inherent in the design of the optic were more sensitive to decentration and change in pupil size.Conclusions: The 3 IOL models demonstrated significant differences in HOAs in response to changes in pupil size, decentration, and tilt angle. All IOL models assessed in this study demonstrated minimal HOA at small pupil diameters. The IOL models with lower, or an absence of, negative spherical aberration were most robust to displacement with increased decentration and tilt angle.