CIRCULATING ANODIC AND CATHODIC ANTIGEN IN SERUM AND URINE FROM SCHISTOSOMA-HAEMATOBIUM - INFECTED CAMEROONIAN CHILDREN RECEIVING PRAZIQUANTEL - A LONGITUDINAL-STUDY
CIRCULATING ANODIC AND CATHODIC ANTIGEN IN SERUM AND URINE FROM SCHISTOSOMA-HAEMATOBIUM - INFECTED CAMEROONIAN CHILDREN RECEIVING PRAZIQUANTEL - A LONGITUDINAL-STUDY
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DOI：
10.1093/clinids/18.3.408
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发表时间：
1994-03-01
影响因子：
11.8
通讯作者：
DEELDER, AM
中科院分区：
文献类型：
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作者：
KREMSNER, PG;ENYONG, P;DEELDER, AM
在吡喹酮治疗前以及治疗后1、2、3、5和12个月，对148名感染血血吸虫的喀麦隆儿童进行了随访。测定产蛋量、病理标志物试剂条指数（RSI）、血清和尿液循环阳极抗原（CAA）和循环阴极抗原（CCA）。入组时，产蛋量中位数为365/10 mL尿；97%的儿童有RSI阳性；在76%的儿童血清和64%的儿童尿液中检测到CAA；55%的儿童血清中检测到CCA， 87%的儿童尿液中检测到CCA。化疗后2个月，产蛋量和RSI明显下降；再感染的发生与血清和尿液中CAA浓度和尿液中CCA浓度的升高同时发生。CAA和CCA的测定有助于诊断、疾病严重程度的评估以及对感染血氧梭菌个体的化疗随访。
A cohort of 148 Cameroonian children infected with Schistosoma haematobium was followed before praziquantel therapy and 1, 2, 3, 5, and 12 months thereafter. Egg output, the reagent strip index (RSI, a pathological marker), and circulating anodic antigen (CAA) and circulating cathodic antigen (CCA) in serum and urine were quantified. At enrollment, the median level of egg output was 365/10 mL of urine; 97% of children had a positive RSI; CAA was detected in serum from 76% of children and in urine from 64%; and CCA was detected in serum from 55% of children and in urine from 87%. Two months after chemotherapy, egg output and RSI had decreased significantly; reinfection later developed in parallel with increases in the serum and urine concentrations of CAA and the urine concentrations of CCA. The measurement of CAA and CCA is useful for diagnosis, evaluation of disease severity, and follow-up of chemotherapy in individuals infected with S. haematobium.