COMPARISON OF THE SEQUENCES OF CLASS-A BETA-LACTAMASES AND OF THE SECONDARY STRUCTURE ELEMENTS OF PENICILLIN-RECOGNIZING PROTEINS
COMPARISON OF THE SEQUENCES OF CLASS-A BETA-LACTAMASES AND OF THE SECONDARY STRUCTURE ELEMENTS OF PENICILLIN-RECOGNIZING PROTEINS
复制标题
DOI：
10.1128/aac.35.11.2294
复制
发表时间：
1991-11-01
影响因子：
4.9
通讯作者：
FRERE, JM
中科院分区：
文献类型：
--
作者：
JORIS, B;LEDENT, P;FRERE, JM
比较了 A 类 β-内酰胺酶的序列。区分了四类主要的酶：来自革兰氏阴性生物和杆菌的酶以及两类不同的链霉菌属酶。金黄色葡萄球菌 PC1 酶虽然在某种程度上更接近芽孢杆菌属酶，但不属于任何 β-内酰胺酶类。这些酶的二级结构元件与C类β-内酰胺酶和链霉菌的二级结构元件之间的相似性。菌株 R61 DD-肽酶也进行了分析，并暂时扩展到 D 类 β-内酰胺酶。为所有青霉素识别酶提出了二级结构元素的统一命名法。
The sequences of class A beta-lactamases were compared. Four main groups of enzymes were distinguished: those from the gram-negative organisms and bacilli and two distinct groups of Streptomyces spp. The Staphylococcus aureus PC1 enzyme, although somewhat closer to the enzyme from the Bacillus group, did not belong to any of the groups of beta-lactamases. The similarities between the secondary structure elements of these enzymes and those of the class C beta-lactamases and of the Streptomyces sp. strain R61 DD-peptidase were also analyzed and tentatively extended to the class D beta-lactamases. A unified nomenclature of secondary structure elements is proposed for all the penicillin-recognizing enzymes.