Neutrophil Intercellular Communication in Acute Lung Injury Emerging Roles of Microparticles and Gap Junctions
Neutrophil Intercellular Communication in Acute Lung Injury Emerging Roles of Microparticles and Gap Junctions
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DOI：
10.1165/rcmb.2012-0472tr
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发表时间：
2013-07-01
影响因子：
6.4
通讯作者：
Schmidt, Eric P.
中科院分区：
文献类型：
--
作者：
Dengler, Viola;Downey, Gregory P.;Schmidt, Eric P.
急性炎症的一个特征是多形核白细胞(中性粒细胞)聚集到感染或损伤的组织中。这种募集的过程是复杂的，包括中性粒细胞和炎症组织之间的多种细胞间通讯机制。在最近对全身和肺血管系统的研究中，人们对细胞间通讯的新形式越来越感兴趣，例如微粒交换和缝隙连接细胞间通讯。为了了解这些新的通信形式在炎症性肺损伤(如急性呼吸窘迫综合征)的发生、发展和缓解中的作用，我们回顾了有关微粒子交换和缝隙连接细胞间通信在肺部炎症过程中对中性粒细胞-肺泡串扰的贡献的文献。通过专注于这些细胞间的通讯，我们的目标是证明知识的重大差距，并确定需要进一步研究急性肺炎症过程的相当需要的领域。
A hallmark of acute inflammation involves the recruitment of polymorphonuclear leukocytes (neutrophils) to infected or injured tissues. The processes underlying this recruitment are complex, and include multiple mechanisms of intercellular communication between neutrophils and the inflamed tissue. In recent studies of the systemic and pulmonary vasculature, interest has increased in novel forms of intercellular communication, such as microparticle exchange and gap junctional intercellular communication. To understand the roles of these novel forms of communication in the onset, progression, and resolution of inflammatory lunginjury (such as acute respiratory distress syndrome), we review the literature concerning the contributions of microparticle exchange and gap junctional intercellular communication to neutrophil-alveolar crosstalk during pulmonary inflammation. By focusing on these cell-cell communications, we aim to demonstrate significant gaps of knowledge and identify areas of considerable need for further investigations of the processes of acute lung inflammation.