An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?
An association and haplotype analysis of porcine maternal infanticide: a model for human puerperal psychosis?
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猪母杀婴的关联和单倍型分析：人类产后精神病的模型？
DOI：
10.1002/ajmg.b.32097
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Quilter CR
中科院分区：
文献类型：
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作者：
Quilter CR
使用 Illumina 猪 SNP60 珠芯片进行关联分析，以确定与猪杀母婴儿显着相关的 SNP。我们之前假设这是人类产后精神病（产后情绪障碍的一种极端形式）的良好动物模型。动物是从经过仔细表型分析的不相关杀婴组和对照组（代表表型谱的极端）中选出的，来自四个不同的品系。比较排列和滑动窗口分析以及分析哪些单倍型处于连锁不平衡 (LD) 状态，以确定一致区域。在所有分析中，SSC 1、3、4、10 和 13 的间隔是恒定的，包含与精神或神经系统疾病相关的基因，并且在多个品系中显着。所有分析和所有品种中最强（接近 GWS）一致的候选区域是位于 SSC3 上的区域，其一个峰值位于 23.4 Mb，与双相情感障碍的候选区域同线，另一个峰值位于 31.9 Mb，与人类产后精神病的候选区域同线（16p13）。从单倍型/LD分析来看，两个区域达到了全基因组显着性（GWS）：第一个区域在SSC4上（KHDRBS3toFAM135B），在一个基于杜洛克的品种中显着（−logP 5.57），并且与人类中与认知和神经质相关的区域是同线性的；第二个是 SSC15，在两个品种中显着（−log10P 5.68），并且包含在大脑中表达的 PAX3。 © 2012 Wiley 期刊公司。
An association analysis using the Illumina porcine SNP60 beadchip was performed to identify SNPs significantly associated with porcine maternal infanticide. We previously hypothesised that this was a good animal model for human puerperal psychosis, an extreme form of postnatal mood disorder. Animals were selected from carefully phenotyped unrelated infanticide and control groups (representing extremes of the phenotypic spectrum), from four different lines. Permutation and sliding window analyses and an analysis to see which haplotypes were in linkage disequilibrium (LD) were compared to identify concordant regions. Across all analyses, intervals on SSCs 1, 3, 4, 10, and 13 were constant, contained genes associated with psychiatric or neurological disorders and were significant in multiple lines. The strongest (near GWS) consistent candidate region across all analyses and all breeds was the one located on SSC3 with one peak at 23.4 Mb, syntenic to a candidate region for bipolar disorder and another at 31.9 Mb, syntenic to a candidate region for human puerperal psychosis (16p13). From the haplotype/LD analysis, two regions reached genome wide significance (GWS): the first on SSC4 (KHDRBS3toFAM135B), which was significant (−logP 5.57) in one Duroc based breed and is syntenic to a region in humans associated with cognition and neurotism; the second on SSC15, which was significant (−log10P 5.68) in two breeds and containedPAX3, which is expressed in the brain. © 2012 Wiley Periodicals, Inc.