Late Event-related Potentials and Schizophrenia
Late Event-related Potentials and Schizophrenia
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晚期事件相关电位和精神分裂症
DOI：
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发表时间：
1979
期刊：
影响因子：
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通讯作者：
B. S. Kopell
中科院分区：
文献类型：
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作者：
W. Roth;T. Horvath;A. Pfefferbaum;J. Tinklenberg;J. Mezzich;B. S. Kopell
事件相关电位(ERP)与精神分裂症的相关性最近在《精神分裂症内置》上的一系列文章中进行了综述[Buchsbaum，1977；Roth，1977；Shagass，1977]。不同潜伏期和地形图分布的事件相关电位成分在患者和对照组之间存在差异，尽管通常一次只应用单一的事件相关电位范例。本文报告了一项先导性研究的结果，该研究旨在采用多重事件相关电位范式设计调查精神分裂症患者。我们对受试者进行了三种范式的测试，每种范式都强调了不同的晚期事件相关电位。潜伏期超过50毫秒的组件通常比早期组件对心理变量(如注意力和预期)更敏感，因此可能对精神分裂症中常见的心理变化更敏感。通过在同一受试者中引出不同的事件相关电位成分，我们希望了解这些成分对精神分裂症疾病的相对敏感性。
Event-related potential (ERP) correlates of schizophrenia have recently been reviewed in a series of articles in the Schizophrenia Builetin [Buchsbaum, 1977; Roth, 1977; Shagass, 1977]. Differences between patients and controls have been found for ERP components of various latencies and topographic distribution although generally only single ERP paradigms have been applied at one time. This paper reports the results of a pilot study designed to investigate schizo phrenic patients in a multiple ERP paradigm design. We tested subjects on three paradigms, each of which emphasized different late ERPs. Components with latencies over 50 msec are generally more sensitive than earlier components to psychological variables, such as attention and expectancy, and for that reason might be more sensitive to psychological alterations commonly reported in schizophrenia. By eliciting different ERP components in the same subjects we hoped to get an idea of the relative sensitivity of these components to schizophrenic illness.