Diffuse optical tomography of highly heterogeneous media
Diffuse optical tomography of highly heterogeneous media
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DOI：
10.1109/42.929613
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发表时间：
2001-06-01
影响因子：
10.6
通讯作者：
Chance, B
中科院分区：
文献类型：
--
作者：
Ntziachristos, V;Hielscher, AH;Chance, B
我们调查的性能扩散光学断层成像高度异质性的媒体，如乳腺组织，作为背景异质性的函数，为了模拟背景异质性，我们采用了功能信息来自钆增强磁共振图像的乳房。我们证明了整体图像质量和量化精度随着背景异质性的增加而增加。此外，我们确认的外观特征文物的边界，规模与背景异质性。这些伪影与临床检查中看到的伪影非常相似，如果不考虑，可能会被误解为实际物体。为了消除伪影和改善整体图像重建，我们应用了一种数据校正算法，该算法产生上级重建结果，并且几乎不依赖于背景异质性的程度。
We investigate the performance of diffuse optical tomography to image highly heterogeneous media, such as breast tissue, as a function of background heterogeneity, To model the background heterogeneity, we have employed the functional information derived from Gadolinium-enhanced magnetic resonance images of the breast. We demonstrate that overall image quality and quantification accuracy worsens as the background heterogeneity increases. Furthermore we confirm the appearance of characteristic artifacts at the boundaries that scale with background heterogeneity. These artifacts are very similar to the ones seen in clinical examinations and can be misinterpreted as actual objects if not accounted for. To eliminate the artifacts and improve the overall image reconstruction, we apply a data-correction algorithm that yields superior reconstruction results and is virtually independent of the degree of the background heterogeneity.