The role of IGF-1R in pediatric malignancies.
The role of IGF-1R in pediatric malignancies.
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DOI：
10.1634/theoncologist.2008-0189
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发表时间：
2009-01
期刊：
影响因子：
--
通讯作者：
Helman LJ
中科院分区：
文献类型：
--
作者：
Kim SY;Toretsky JA;Scher D;Helman LJ
胰岛素样生长因子（IGF）家族由配体（IGF-I、IGF-II、胰岛素）、几种受体（包括IGF-1 R）和六种结合蛋白（IGFBP-1至IGFBP-6）组成。该家族的成员调节关键的细胞活动，并且在成人和儿童癌症的发展和进展中也起着重要作用。配体与受体的结合导致其活化，随后沿着沿着几条途径进行信号转导。在某些儿童恶性肿瘤中，IGF-1 R可通过内分泌、自分泌或旁分泌机制激活。虽然IGF-1 R的突变尚未确定，但这种信号通路在许多儿童癌症中上调。这些发现导致了一系列IGF-1 R信号调节剂的开发，目前正在临床试验中进行测试。本文综述了IGF-1 R在儿童恶性肿瘤中的作用。
The insulin-like growth factor (IGF) family consists of ligands (IGF-I, IGF-II, insulin), several receptors (including IGF-1R), and six binding proteins (IGFBP-1 through IGFBP-6). Members of this family regulate key cellular activities and they also play an important role in the development and progression of both adult and childhood cancers. Binding of a ligand to the receptor leads to its activation, followed by signal transduction along several pathways. In some childhood malignancies, IGF-1R can be activated by endocrine, autocrine, or paracrine mechanisms. Although mutations in IGF-1R have not been identified, this signaling pathway is upregulated in many childhood cancers. These findings have led to the development of a host of IGF-1R signaling modulators that are currently being tested in clinical trials. This review explores the role of IGF-1R in a range of childhood malignancies.
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影响因子：
1.4
作者：
Ayalon, D.;Glaser, T.;Werner, H.
通讯作者：
Werner, H.
影响因子：
11.2
作者：
Janeway, Katherine A.;Liegl, Bernadette;Fletcher, Jonathan A.
通讯作者：
Fletcher, Jonathan A.
DOI：
10.1111/j.1432-1033.1996.00523.x
发表时间：
1996-03-01
期刊：
EUROPEAN JOURNAL OF BIOCHEMISTRY
影响因子：
--
作者：
Giuliano, M;Vento, R;Tesoriere, G
通讯作者：
Tesoriere, G
影响因子：
10.3
作者：
Bjornsson, Hans T.;Brown, Lindsey J.;Feinberg, Andrew P.
通讯作者：
Feinberg, Andrew P.
影响因子：
11.5
作者：
Agaram, Narasimhan P.;Laquaglia, Michael P.;Antonescu, Cristina R.
通讯作者：
Antonescu, Cristina R.