Identification and Enrichment of alpha-Glucosidase-Inhibiting Dihydrostilbene and Flavonoids from Glycyrrhiza uralensis Leaves
Identification and Enrichment of alpha-Glucosidase-Inhibiting Dihydrostilbene and Flavonoids from Glycyrrhiza uralensis Leaves
复制标题
乌拉尔甘草叶中抑制α-葡萄糖苷酶的二氢芪和黄酮类化合物的鉴定和富集
DOI：
10.1021/acs.jafc.6b04155
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发表时间：
2017
影响因子：
6.1
通讯作者：
Chao-Mei Ma
中科院分区：
文献类型：
--
作者：
Rigui Ye;Yu-Hong Fan;Chao-Mei Ma
To exploitGlycyrrhiza uralensisresources, we examined the bioactive constituents ofG. uralensisleaves. Seven chemical components were isolated by repeat column chromatography, and using spectroscopic methods, their structures were determined to be a novel prenylated dihydrostilbene, α,α′-dihydro-3,5,3′,4′-tetrahydroxy-2,5′-diprenylstilbene (1); a methylated flavonoid, quercetin-3-Me ether (4); and 5 prenylated flavonoids: 5′-prenylquercetin (3), 8-[(E)-3-hydroxymethyl-2-butenyl]eriodictyol (7), 6-prenyleriodictyol (5), 5′-prenyleriodictyol (6), and 6-prenylquercetin-3-Me ether (2). Compounds1–7and their unprenylated counterparts, glycosides, and other related compounds (8–13) were quantitatively analyzed. Using a macroporous resin column, most of these compounds could be enriched in the 40% to 60% ethanol-eluted fractions. Compounds1–7showed strong radical scavenging activity toward DPPH, and most of them demonstrated greater inhibitory activity against α-glucosidase than their unprenylated counterparts.
