CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis
CD44S-hyaluronan interactions protect cells resulting from EMT against anoikis
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DOI：
10.1016/j.matbio.2015.04.010
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发表时间：
2015-10-01
期刊：
影响因子：
6.9
通讯作者：
Frisch, Steven M.
中科院分区：
文献类型：
--
作者：
Cieply, Benjamin;Koontz, Colton;Frisch, Steven M.
正常上皮细胞从基质中脱离，在稳态转换过程中触发称为失巢凋亡的凋亡反应。转移性肿瘤细胞逃避失巢凋亡的机制，只有部分特征。特别是，在侵袭性肿瘤细胞亚群中的上皮-间质转化（EMT）赋予失巢凋亡抗性。在一些情况下，EMT上调癌症干细胞标志物CD 44 S和透明质酸合酶-2（HAS 2）。CD 44 S是细胞外基质中透明质酸的主要受体。在此，我们证明，CD 44 S，不像在正常上皮细胞中表达的CD 44 E亚型，有助于防止失巢凋亡。这种保护需要CD 44 S与透明质酸（HA）的相互作用。提出CD 44 S HA相互作用通过在分离条件下增强细胞存活在肿瘤转移中发挥重要作用。(C)2015年由Elsevier B. V.出版
The detachment of normal epithelial cells from matrix triggers an apoptotic response known as anoikis, during homeostatic turnover. Metastatic tumor cells evade anoikis, by mechanisms that are only partly characterized. In particular, the epithelial-mesenchymal transition (EMT) in a subset of invasive tumor cells confers anoikis-resistance. In some cases, EMT up-regulates the cancer stem cell marker CD44S and the enzyme hyaluronic acid synthase-2 (HAS2). CD44S is the major receptor for hyaluronan in the extracellular matrix. Herein, we demonstrate that CD44S, unlike the CD44E isoform expressed in normal epithelial cells, contributes to the protection against anoikis. This protection requires the interaction of CD44S with hyaluronan (HA). CD44S HA interaction is proposed to play an important role in tumor metastasis through enhanced cell survival under detached conditions. (C) 2015 Published by Elsevier B.V.