The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study
The association between subclinical thyroid dysfunction and dementia: The Health, Aging and Body Composition (Health ABC) Study
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DOI：
10.1111/cen.13458
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发表时间：
2017-11-01
影响因子：
3.2
通讯作者：
Rodondi, Nicolas
中科院分区：
文献类型：
--
作者：
Aubert, Carole E.;Bauer, Douglas C.;Rodondi, Nicolas
目的：关于亚临床甲状腺功能障碍与痴呆症之间的联系的数据有限且相互矛盾。我们的目标是确定亚临床甲状腺功能障碍是否与痴呆症和认知功能下降有关。设计：基于人群的前瞻性队列研究。患者：70-79岁的成年人，测量甲状腺功能，但在基线和随访时没有痴呆，并在基线和随访时进行修订的简易精神状态(3MS)。测量：主要结果是事件判定的痴呆，基于3MS，医院记录和痴呆症药物。次要结果是3MS的改变。结果：在2558名成人中，85%的人甲状腺功能正常(TSH0.45~4.49mIU/L)，2%的人亚临床甲亢伴TSH轻度下降(TSH0.10~0.44mIU/L)，1%的亚临床甲亢伴TSH抑制(TSH0.10~0.44mIU/L)
Objective: Data on the association between subclinical thyroid dysfunction and dementia are limited and conflicting. We aimed to determine whether subclinical thyroid dysfunction was associated with dementia and cognitive decline.Design: Population-based prospective cohort study.Patients: Adults aged 70-79years with measured thyroid function, but no dementia at baseline, and Modified Mini-Mental State (3MS) at baseline and follow-up.Measurements: Primary outcome was incident-adjudicated dementia, based on 3MS, hospital records and dementia drugs. Secondary outcome was change in 3MS. Models were adjusted for age, sex, race, education and baseline 3MS, and then further for cardiovascular risk factors.Results: Among 2558 adults, 85% were euthyroid (TSH 0.45-4.49mIU/L), 2% had subclinical hyperthyroidism with mildly decreased TSH (TSH 0.10-0.44mIU/L), 1% subclinical hyperthyroidism with suppressed TSH (TSH