Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer.
Differential regulation of oestrogen receptor β isoforms by 5' untranslated regions in cancer.
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DOI：
10.1111/j.1582-4934.2009.00867.x
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发表时间：
2010-08
影响因子：
5.3
通讯作者：
Hughes TA
中科院分区：
文献类型：
--
作者：
Smith L;Brannan RA;Hanby AM;Shaaban AM;Verghese ET;Peter MB;Pollock S;Satheesha S;Szynkiewicz M;Speirs V;Hughes TA
Oestrogen receptors (ERs) are critical regulators of the behaviour of many cancers. Despite this, the roles and regulation of one of the two known ERs – ERβ– are poorly understood. This is partly because analyses have been confused by discrepancies between ERβ expression at mRNA and proteins levels, and because ERβ is expressed as several functionally distinct isoforms. We investigated human ERβ 5′ untranslated regions (UTRs) and their influences on ERβ expression and function. We demonstrate that two alternative ERβ 5′UTRs have potent and differential influences on expression acting at the level of translation. We show that their influences are modulated by cellular context and in carcinogenesis, and demonstrate the contributions of both upstream open reading frames and RNA secondary structure. These regulatory mechanisms offer explanations for the non-concordance of ERβ mRNA and protein. Importantly, we also demonstrate that 5′UTRs allow the first reported mechanisms for differential regulation of the expression of the ERβ isoforms 1, 2 and 5, and thereby have critical influences on ERβ function.
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DOI：
10.1083/jcb.115.4.887
发表时间：
1991-11
期刊：
The Journal of cell biology
影响因子：
--
作者：
Kozak M
通讯作者：
Kozak M
影响因子：
8.8
作者：
Coleman, L. J.;Peter, M. B.;Teall, T. J.;Brannan, R. A.;Hanby, A. M.;Honarpisheh, H.;Shaaban, A. M.;Smith, L.;Speirs, V.;Verghese, E. T.;McElwaine, J. N.;Hughes, T. A.
通讯作者：
Hughes, T. A.
影响因子：
3.7
作者：
Hughes, TA;Brady, HJM
通讯作者：
Brady, HJM
影响因子：
4.8
作者：
Gendra, Elisenda;Colgan, Diana F.;Konarska, Maria M.
通讯作者：
Konarska, Maria M.
影响因子：
3.9
作者：
Galluzzo, Paola;Caiazza, Francesco;Marino, Maria
通讯作者：
Marino, Maria