Cardiorespiratory fitness is associated with inflammation and physical activity in HIV+ adults.
Cardiorespiratory fitness is associated with inflammation and physical activity in HIV+ adults.
复制标题
心肺健康与艾滋病毒成人的炎症和体力活动有关。
DOI：
10.1097/qad.0000000000002154
复制
发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Josephson,Richard
中科院分区：
文献类型：
--
作者：
Webel,AllisonR;Jenkins,Trevor;Vest,Marianne;Oliveira,VitorHF;Longenecker,ChrisT;Liu,Jintao;Currie,Jackson;Sattar,Abdus;Josephson,Richard
Objective:Our objective was to examine the effect of a lifestyle diet and exercise intervention on cardiorespiratory fitness (CRF) and to examine predictors of change in CRF.Design:People living with HIV (PLHIV) are at increased risk for cardiovascular disease. CRF is a better predictor of cardiovascular disease-related mortality than established risk factors yet very little is known about CRF in PLHIV.Methods:One-hundred and seven virally suppressed PLHIV were randomized to a group-based intervention to improve lifestyle behaviors or a control condition. All PLHIV maximal cardiorespiratory stress test to determine VO 2 peak, VO 2 at anaerobic threshold, and ventilatory efficiency/VCO 2, at baseline and 6 months later. Participants wore an accelerometer to measure physical activity, completed waist–hip circumference measures, and had a fasting lipid profile, IL-6, and high sensitivity C-reactive protein analyzed. Generalized estimating equations were used to examine the effect of the intervention on CRF and predictors of change in CRF.Results:Participants were approximately 53 years old, 65% male (n= 70), and 86% African-American (n= 93). There was no effect of the intervention on markers of CRF over time (P> 0.05). After controlling for age, sex, waist–hip-ratio, the inflammatory biomarker IL-6 was inversely associated with a decline in both VO 2 peak (P= 0.03) and VO 2 at anaerobic threshold (P= 0.03). In addition, participants who walked an additional 10 000 steps per day had a 2.69 ml/kg per min higher VO 2 peak (P= 0.02).Conclusion:Despite HIV viral suppression, PLHIV had remarkably poor CRF and inflammation was associated with a clinically adverse CRF profile. However, increased physical activity was associated with improved CRF.
